{"id":64417,"date":"2023-11-05T17:35:00","date_gmt":"2023-11-05T08:35:00","guid":{"rendered":"https:\/\/nihon-hanzai-jiken.com\/?p=64417"},"modified":"2023-11-07T03:06:49","modified_gmt":"2023-11-06T18:06:49","slug":"%e3%80%90%e9%81%ba%e4%bc%9d%e5%ad%90%e3%83%87%e3%83%bc%e3%82%bf%e5%88%86%e6%9e%90%e3%80%91%e4%b9%9d%e5%b7%9e%e4%ba%ba%e3%81%af%e3%81%94%e7%94%a8%e5%bf%83-%e3%80%8c%e8%82%a5%e6%ba%80%e5%9e%8b%e3%81%a7","status":"publish","type":"post","link":"https:\/\/nihon-hanzai-jiken.com\/?p=64417","title":{"rendered":"\u3010\u907a\u4f1d\u5b50\u30c7\u30fc\u30bf\u5206\u6790\u3011\u4e5d\u5dde\u4eba\u306f\u3054\u7528\u5fc3 \u300c\u80a5\u6e80\u578b\u3067\u4e2d\u6027\u8102\u80aa\u304c\u9ad8\u3044\u300d\u30bf\u30a4\u30d7\u304c\u591a\u3044\u90fd\u9053\u5e9c\u770c 3\u4f4d\u306f\u9e7f\u5150\u5cf6\u30012\u4f4d\u4f50\u8cc0"},"content":{"rendered":"

\u682a\u5f0f\u4f1a\u793e\u30e6\u30fc\u30b0\u30ec\u30ca\uff08\u6771\u4eac\u90fd\u6e2f\u533a\uff09\u306f\u3001\u30e6\u30fc\u30b0\u30ec\u30ca\u30fb\u30de\u30a4\u30d8\u30eb\u30b9\u3068\u30b8\u30fc\u30f3\u30af\u30a8\u30b9\u30c8\u306e\u907a\u4f1d\u5b50\u89e3\u6790\u30b5\u30fc\u30d3\u30b9\u306e\u30b2\u30ce\u30e0\u30c7\u30fc\u30bf\u3092\u3082\u3068\u306b\u3057\u305f\u3001\u300c\u80a5\u6e80\u578b\u3067\u4e2d\u6027\u8102\u80aa\u304c\u9ad8\u3044\u907a\u4f1d\u5b50\u30bf\u30a4\u30d7\u304c\u591a\u3044\u90fd\u9053\u5e9c\u770c\uff08\u51fa\u751f\u5730\uff09\u30e9\u30f3\u30ad\u30f3\u30b0\u300d\u3092\u767a\u8868\u3057\u307e\u3057\u305f\u3002
\n\u3010\u8868\u3011\u80a5\u6e80\u578b\u3067\u4e2d\u6027\u8102\u80aa\u304c\u9ad8\u3044\u907a\u4f1d\u5b50\u30bf\u30a4\u30d7\u304c\u591a\u3044\u90fd\u9053\u5e9c\u770c\u30e6\u30fc\u30b0\u30ec\u30ca\u30fb\u30de\u30a4\u30d8\u30eb\u30b9\u3068\u30b8\u30fc\u30f3\u30af\u30a8\u30b9\u30c8\u304c\u63d0\u4f9b\u3059\u308b\u907a\u4f1d\u5b50\u89e3\u6790\u30b5\u30fc\u30d3\u30b9\u306f\u3001\u500b\u4eba\u306e\u5065\u5eb7\u30ea\u30b9\u30af\u30fb\u4f53\u8cea\u30fb\u7956\u5148\u306b\u3064\u3044\u3066\u3001300\u9805\u76ee\u4ee5\u4e0a\u306e\u907a\u4f1d\u5b50\u578b\u3092\u89e3\u6790\u3057\u3001\u3069\u306e\u3088\u3046\u306a\u75c5\u6c17\u306b\u304b\u304b\u308a\u3084\u3059\u3044\u304b\u3001\u3069\u306e\u3088\u3046\u306a\u4f53\u8cea\u306e\u907a\u4f1d\u7684\u50be\u5411\u304c\u3042\u308b\u304b\u306b\u3064\u3044\u3066\u3001\u7d50\u679c\u3092\u63d0\u4f9b\u3059\u308b\u30b5\u30fc\u30d3\u30b9\u3060\u305d\u3046\u3067\u3059\u3002<\/p>\n

\u6442\u53d6\u3055\u308c\u305f\u98df\u7269\u306e\u4e2d\u3067\u3001\u30a8\u30cd\u30eb\u30ae\u30fc\u3068\u3057\u3066\u4f7f\u308f\u308c\u306a\u304b\u3063\u305f\u7cd6\u8cea\u3084\u8102\u80aa\u306f\u3001\u5927\u90e8\u5206\u304c\u76ae\u4e0b\u8102\u80aa\u3068\u3057\u3066\u84c4\u3048\u3089\u308c\u307e\u3059\u304c\u3001\u305d\u306e\u307b\u3068\u3093\u3069\u304c\u300c\u4e2d\u6027\u8102\u80aa\u300d\u3067\u3042\u308b\u3068\u3044\u3044\u307e\u3059\u3002\u300c\u4e2d\u6027\u8102\u80aa\uff08\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\uff09\u300d\u306f\u3001\u666e\u6bb5\u306f\u809d\u81d3\u30fb\u76ae\u4e0b\u30fb\u8840\u6db2\u4e2d\u306b\u5b58\u5728\u3057\u3001\u7cd6\u8cea\u304c\u4e0d\u8db3\u3059\u308b\u306a\u3069\u3057\u305f\u5834\u5408\u3001\u5fc5\u8981\u306b\u5fdc\u3058\u3066\u30a8\u30cd\u30eb\u30ae\u30fc\u6e90\u3068\u3057\u3066\u6d88\u8cbb\u3001\u4ee3\u8b1d\u3055\u308c\u308b\u4e00\u65b9\u3067\u3001\u8840\u6db2\u4e2d\u306e\u4e2d\u6027\u8102\u80aa\u6fc3\u5ea6\u304c\u9ad8\u3044\u3068\u3001\u80a5\u6e80\u75c7\u3084\u8102\u80aa\u809d\u306b\u306a\u308a\u3084\u3059\u3044\u3068\u3044\u308f\u308c\u3066\u3044\u307e\u3059\u3002\u307e\u305f\u3001\u8102\u8cea\u4ee3\u8b1d\u306b\u95a2\u4e0e\u3059\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u308b\u907a\u4f1d\u5b50\u306b\u300cAPOA5\uff08\u30a2\u30dd\u30ea\u30dd\u30bf\u30f3\u30d1\u30af\u8ceaA5\uff09\u300d\u304c\u3042\u308a\u307e\u3059\u3002\u4e2d\u56fd\u306e\u6d59\u6c5f\u5927\u5b66\u306e\u7814\u7a76\u30c1\u30fc\u30e0\u304c\u3001\u9ad8\u30b0\u30ea\u30bb\u30ea\u30c9\u8840\u75c7\u3068\u306e\u7814\u7a76\u304c\u5e83\u304f\u884c\u308f\u308c\u3066\u3044\u308b\u300cAPOA5\u300d\u907a\u4f1d\u5b50\u306b\u6ce8\u76ee\u3057\u3066\u5b50\u3069\u3082\u306e\u6642\u671f\u306e\u80a5\u6e80\u3068\u95a2\u9023\u304c\u3042\u308b\u306e\u304b\u8abf\u3079\u307e\u3057\u305f\u3002700\u4eba\u4ee5\u4e0a\u306e\u4e2d\u56fd\u4eba\u306e\u82e5\u8005\u3092\u5bfe\u8c61\u306b\u8abf\u67fb\u3092\u884c\u3063\u305f\u7d50\u679c\u3001\u300cSNP\uff1ars651821\u300d\u3068\u3044\u3046\u907a\u4f1d\u5b50\u578b\u306b\u304a\u3044\u3066\u300cC\u300d\u3092\u6301\u3063\u3066\u3044\u308b\u4eba\u307b\u3069\u300c\u80a5\u6e80\u307e\u305f\u306f\u904e\u4f53\u91cd\u300d\u306e\u50be\u5411\u304c\u3042\u308a\u3001\u8840\u6db2\u4e2d\u306eHDL\uff08\u5584\u7389\uff09\u4ee5\u5916\u306e\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u6fc3\u5ea6\u3084\u4e2d\u6027\u8102\u80aa\uff08\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\uff09\u6fc3\u5ea6\u3082\u9ad8\u3044\u50be\u5411\u304c\u3042\u308b\u3068\u5206\u304b\u308a\u307e\u3057\u305f\u3002\uff08\u203b\uff09\uff08\u203b\uff09Zhu WF et al. \uff082014\uff09 “Triglyceride-raising APOA5 genetic variants are associated with obesity and non-HDL-C in Chinese children and adolescents.” Lipids Health Dis. 13:93.\u305d\u3053\u3067\u3001\u672c\u8abf\u67fb\u3067\u306f\u30c0\u30a4\u30a8\u30c3\u30c8\u306e\u89b3\u70b9\u304b\u3089\u8102\u8cea\u4ee3\u8b1d\u306b\u95a2\u308f\u308b\u907a\u4f1d\u5b50\u306e\u907a\u4f1d\u5b50\u591a\u578b\u3068\u80a5\u6e80\u50be\u5411\u30fb\u4f53\u8cea\u306e\u95a2\u4fc2\u3092\u307f\u305f\u9805\u76ee\u300c\u30c0\u30a4\u30a8\u30c3\u30c8\u3010\u8102\u8cea\u4ee3\u8b1d\u3011\uff08SNP\uff1ars651821\uff09\u300d\u306b\u6ce8\u76ee\u30022023\u5e749\u6708\u306b\u540c\u30b5\u30fc\u30d3\u30b9\u306e\u5229\u7528\u8005\u306e\u4e2d\u304b\u30892\u4e071371\u4eba\u306e\u30b2\u30ce\u30e0\u30c7\u30fc\u30bf\u3092\u7528\u3044\u3066\u3001\u300c\u6a19\u6e96\u578b\u306b\u591a\u3044\u30bf\u30a4\u30d7\uff08\u907a\u4f1d\u5b50\u578b\uff1aTT\uff09\u300d\u3001\u300c\u80a5\u6e80\u578b\u306b\u591a\u304f\u8840\u4e2d\u8102\u8cea\u6fc3\u5ea6\u304c\u9ad8\u3044\u30bf\u30a4\u30d7\uff08\u907a\u4f1d\u5b50\u578b\uff1aCT\uff09\u300d\u3001\u300c\u80a5\u6e80\u578b\u306b\u591a\u304f\u8840\u4e2d\u8102\u8cea\u6fc3\u5ea6\u304c\u9ad8\u3044\u30bf\u30a4\u30d7\uff08\u907a\u4f1d\u5b50\u578b\uff1aCC\uff09\u300d\u306e3\u3064\u306e\u30bf\u30a4\u30d7\u306e\u306a\u304b\u304b\u3089\u300c\u80a5\u6e80\u578b\u306b\u591a\u304f\u8840\u4e2d\u8102\u8cea\u6fc3\u5ea6\u304c\u9ad8\u3044\u30bf\u30a4\u30d7\u300d\u3067\u3042\u308b\u300cCT\u300d\u3068\u300cCC\u300d\u306e\u907a\u4f1d\u5b50\u578b\u3092\u300c\u80a5\u6e80\u578b\u3067\u4e2d\u6027\u8102\u80aa\u304c\u9ad8\u3044\u907a\u4f1d\u5b50\u30bf\u30a4\u30d7\u300d\u3068\u3057\u3001\u8a72\u5f53\u3059\u308b\u4eba\u306e\u5272\u5408\u3092\u90fd\u9053\u5e9c\u770c\u3054\u3068\u306b\u7b97\u51fa\u3057\u3001\u6570\u5024\u5316\u3057\u307e\u3057\u305f\u3002\u305d\u306e\u7d50\u679c\u3001\u300c\u80a5\u6e80\u578b\u3067\u4e2d\u6027\u8102\u80aa\u304c\u9ad8\u3044\u907a\u4f1d\u5b50\u30bf\u30a4\u30d7\u304c\u591a\u3044\u90fd\u9053\u5e9c\u770c\u300d\u306e1\u4f4d\u306f\u300c\u6c96\u7e04\u770c\u300d\uff0869.95%\uff09\u3068\u306a\u308a\u307e\u3057\u305f\u3002\u4ee5\u4e0b\u30012\u4f4d\u300c\u4f50\u8cc0\u770c\u300d\uff0863.76%\uff09\u30013\u4f4d\u300c\u9e7f\u5150\u5cf6\u770c\u300d\uff0861.99%\uff09\u30014\u4f4d\u300c\u79cb\u7530\u770c\u300d\uff0861.67%\uff09\u30015\u4f4d\u300c\u5cf6\u6839\u770c\u300d\uff0860.00%\uff09\u30016\u4f4d\u300c\u798f\u5cf6\u770c\u300d\uff0859.94%\uff09\u30017\u4f4d\u300c\u5bae\u57ce\u770c\u300d\uff0859.67%\uff09\u30018\u4f4d\u300c\u5c71\u5f62\u770c\u300d\uff0858.96%\uff09\u30019\u4f4d\u300c\u5bae\u5d0e\u770c\u300d\uff0858.94%\uff09\u300110\u4f4d\u300c\u65b0\u6f5f\u770c\u300d\uff0858.70%\uff09\u3068\u7d9a\u304d\u3001\u4e5d\u5dde\u3084\u6771\u5317\u5404\u770c\u304c\u4e0a\u4f4d\u306b\u5165\u308b\u7d50\u679c\u3068\u306a\u308a\u307e\u3057\u305f\u3002\u4e00\u65b9\u3001\u300c\u80a5\u6e80\u578b\u3067\u4e2d\u6027\u8102\u80aa\u304c\u9ad8\u3044\u907a\u4f1d\u5b50\u30bf\u30a4\u30d7\u304c\u5c11\u306a\u3044\u90fd\u9053\u5e9c\u770c\u300d\u306f\u3001\u5c11\u306a\u3044\u9806\u306b\u300c\u9ad8\u77e5\u770c\u300d\uff0851.52\uff05\uff09\u3001\u300c\u9759\u5ca1\u770c\u300d\uff0852.54\uff05\uff09\u3001\u300c\u5927\u962a\u5e9c\u300d\uff0852.64\uff05\uff09\u3001\u300c\u6803\u6728\u770c\u300d\uff0852.71\uff05\uff09\u3001\u300c\u9577\u91ce\u770c\u300d\uff0852.99\uff05\uff09\u3068\u306a\u3063\u3066\u3044\u307e\u3059\u3002\u306a\u304a\u3001\u6771\u4eac\u5927\u5b66\u306e\u7814\u7a76\u30c1\u30fc\u30e0\u304c2023\u5e742\u6708\u306b\u30a2\u30e1\u30ea\u30ab\u306e\u79d1\u5b66\u8a8c\u300e\u30a2\u30a4\u30b5\u30a4\u30a8\u30f3\u30b9\uff08iScience\uff09\u300f\u306e\u30aa\u30f3\u30e9\u30a4\u30f3\u7248\u3067\u767a\u8868\u3057\u305f\u7814\u7a76\u8ad6\u6587\uff08\u203b\uff09\u3067\u306f\u3001\u7e04\u6587\u4eba\u7531\u6765\u306e\u907a\u4f1d\u5b50\u591a\u578b\u3092\u591a\u304f\u6301\u3063\u3066\u3044\u308b\u300c\u201d\u7e04\u6587\u5ea6\u201d\u304c\u9ad8\u3044\u5730\u57df\u300d\u3068\u3057\u3066\u3001\u4e00\u756a\u9ad8\u3044\u306e\u306f\u300c\u6c96\u7e04\u770c\u300d\u3067\u3001\u6b21\u3044\u3067\u300c\u6771\u5317\u5404\u770c\u300d\u3084\u4e5d\u5dde\u3067\u306f\u300c\u9e7f\u5150\u5cf6\u770c\u300d\u3001\u4e2d\u56fd\u5730\u65b9\u3067\u306f\u300c\u5cf6\u6839\u770c\u300d\u3068\u5831\u544a\u3055\u308c\u3066\u304a\u308a\u3001\u672c\u8abf\u67fb\u306e\u300c\u80a5\u6e80\u578b\u3067\u4e2d\u6027\u8102\u80aa\u304c\u9ad8\u3044\u907a\u4f1d\u5b50\u30bf\u30a4\u30d7\u304c\u591a\u3044\u90fd\u9053\u5e9c\u770c\u30e9\u30f3\u30ad\u30f3\u30b0\u300d\u306e\u4e0a\u4f4d\u306b\u5165\u3063\u305f\u5730\u57df\u3068\u975e\u5e38\u306b\u4f3c\u3066\u3044\u308b\u3053\u3068\u304c\u898b\u3066\u53d6\u308c\u307e\u3057\u305f\u3002\u3061\u306a\u307f\u306b\u3001\u7e04\u6587\u4eba\u7531\u6765\u306e\u907a\u4f1d\u5b50\u591a\u578b\u3067\u3042\u308b\u300c\u8840\u7cd6\u5024\u304a\u3088\u3073\u4e2d\u6027\u8102\u80aa\u3092\u9ad8\u3081\u308b\u300d\u907a\u4f1d\u7684\u56e0\u5b50\u306f\u3001\u73fe\u4ee3\u306e\u65e5\u672c\u4eba\u306b\u3068\u3063\u3066\u306f\u80a5\u6e80\u306e\u8981\u56e0\u3068\u306a\u308b\u3082\u306e\u306e\u3001\u7e04\u6587\u4eba\u306b\u3068\u3063\u3066\u306f\u3001\u8840\u7cd6\u5024\u3084\u4e2d\u6027\u8102\u80aa\u3092\u9ad8\u304f\u7dad\u6301\u3059\u308b\u3053\u3068\u3067\u5e38\u306b\u98df\u6599\u3092\u5165\u624b\u3067\u304d\u308b\u308f\u3051\u3067\u306f\u306a\u3044\u72e9\u731f\u63a1\u96c6\u751f\u6d3b\u306b\u9069\u5fdc\u3057\u3066\u3044\u305f\u53ef\u80fd\u6027\u304c\u3042\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002\uff08\u203b\uff09Watanabe, Yusuke, and Jun Ohashi. \uff082023\uff09 \u201cModern Japanese ancestry-derived variants reveal the formation process of the current Japanese regional gradations.\u201d iScience. 3;26\uff083\uff09:106130\u307e\u305f\u3001\u300c\u80a5\u6e80\u578b\u306b\u591a\u304f\u8840\u4e2d\u8102\u8cea\u6fc3\u5ea6\u304c\u9ad8\u3044\u30bf\u30a4\u30d7\uff08\u907a\u4f1d\u5b50\u578b\uff1aCT\uff09\u300d\u306b\u8a72\u5f53\u3059\u308b\u65e5\u672c\u4eba\u306e\u5272\u5408\u306f45.6\uff05\u3001\u300c\u80a5\u6e80\u578b\u306b\u591a\u304f\u8840\u4e2d\u8102\u8cea\u6fc3\u5ea6\u304c\u9ad8\u3044\u30bf\u30a4\u30d7\uff08\u907a\u4f1d\u5b50\u578b\uff1aCC\uff09\u300d\u3067\u306f11.8\uff05\u3068\u306a\u3063\u305f\u3053\u3068\u304b\u3089\u3001\u65e5\u672c\u4eba\u306e\u7d046\u5272\u304c\u300c\u80a5\u6e80\u578b\u3067\u4e2d\u6027\u8102\u80aa\u304c\u9ad8\u3044\u907a\u4f1d\u5b50\u30bf\u30a4\u30d7\u300d\u306b\u8a72\u5f53\u3059\u308b\u3053\u3068\u304c\u63a8\u6e2c\u3055\u308c\u308b\u3068\u3057\u3066\u3044\u307e\u3059\u3002
\n\u30e6\u30fc\u30b0\u30ec\u30ca\u30fb\u30de\u30a4\u30d8\u30eb\u30b9\u3068\u30b8\u30fc\u30f3\u30af\u30a8\u30b9\u30c8\u304c\u63d0\u4f9b\u3059\u308b\u907a\u4f1d\u5b50\u89e3\u6790\u30b5\u30fc\u30d3\u30b9\u306f\u3001\u500b\u4eba\u306e\u5065\u5eb7\u30ea\u30b9\u30af\u30fb\u4f53\u8cea\u30fb\u7956\u5148\u306b\u3064\u3044\u3066\u3001300\u9805\u76ee\u4ee5\u4e0a\u306e\u907a\u4f1d\u5b50\u578b\u3092\u89e3\u6790\u3057\u3001\u3069\u306e\u3088\u3046\u306a\u75c5\u6c17\u306b\u304b\u304b\u308a\u3084\u3059\u3044\u304b\u3001\u3069\u306e\u3088\u3046\u306a\u4f53\u8cea\u306e\u907a\u4f1d\u7684\u50be\u5411\u304c\u3042\u308b\u304b\u306b\u3064\u3044\u3066\u3001\u7d50\u679c\u3092\u63d0\u4f9b\u3059\u308b\u30b5\u30fc\u30d3\u30b9\u3060\u305d\u3046\u3067\u3059\u3002
\n\u6442\u53d6\u3055\u308c\u305f\u98df\u7269\u306e\u4e2d\u3067\u3001\u30a8\u30cd\u30eb\u30ae\u30fc\u3068\u3057\u3066\u4f7f\u308f\u308c\u306a\u304b\u3063\u305f\u7cd6\u8cea\u3084\u8102\u80aa\u306f\u3001\u5927\u90e8\u5206\u304c\u76ae\u4e0b\u8102\u80aa\u3068\u3057\u3066\u84c4\u3048\u3089\u308c\u307e\u3059\u304c\u3001\u305d\u306e\u307b\u3068\u3093\u3069\u304c\u300c\u4e2d\u6027\u8102\u80aa\u300d\u3067\u3042\u308b\u3068\u3044\u3044\u307e\u3059\u3002
\n\u300c\u4e2d\u6027\u8102\u80aa\uff08\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\uff09\u300d\u306f\u3001\u666e\u6bb5\u306f\u809d\u81d3\u30fb\u76ae\u4e0b\u30fb\u8840\u6db2\u4e2d\u306b\u5b58\u5728\u3057\u3001\u7cd6\u8cea\u304c\u4e0d\u8db3\u3059\u308b\u306a\u3069\u3057\u305f\u5834\u5408\u3001\u5fc5\u8981\u306b\u5fdc\u3058\u3066\u30a8\u30cd\u30eb\u30ae\u30fc\u6e90\u3068\u3057\u3066\u6d88\u8cbb\u3001\u4ee3\u8b1d\u3055\u308c\u308b\u4e00\u65b9\u3067\u3001\u8840\u6db2\u4e2d\u306e\u4e2d\u6027\u8102\u80aa\u6fc3\u5ea6\u304c\u9ad8\u3044\u3068\u3001\u80a5\u6e80\u75c7\u3084\u8102\u80aa\u809d\u306b\u306a\u308a\u3084\u3059\u3044\u3068\u3044\u308f\u308c\u3066\u3044\u307e\u3059\u3002
\n\u307e\u305f\u3001\u8102\u8cea\u4ee3\u8b1d\u306b\u95a2\u4e0e\u3059\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u308b\u907a\u4f1d\u5b50\u306b\u300cAPOA5\uff08\u30a2\u30dd\u30ea\u30dd\u30bf\u30f3\u30d1\u30af\u8ceaA5\uff09\u300d\u304c\u3042\u308a\u307e\u3059\u3002\u4e2d\u56fd\u306e\u6d59\u6c5f\u5927\u5b66\u306e\u7814\u7a76\u30c1\u30fc\u30e0\u304c\u3001\u9ad8\u30b0\u30ea\u30bb\u30ea\u30c9\u8840\u75c7\u3068\u306e\u7814\u7a76\u304c\u5e83\u304f\u884c\u308f\u308c\u3066\u3044\u308b\u300cAPOA5\u300d\u907a\u4f1d\u5b50\u306b\u6ce8\u76ee\u3057\u3066\u5b50\u3069\u3082\u306e\u6642\u671f\u306e\u80a5\u6e80\u3068\u95a2\u9023\u304c\u3042\u308b\u306e\u304b\u8abf\u3079\u307e\u3057\u305f\u3002700\u4eba\u4ee5\u4e0a\u306e\u4e2d\u56fd\u4eba\u306e\u82e5\u8005\u3092\u5bfe\u8c61\u306b\u8abf\u67fb\u3092\u884c\u3063\u305f\u7d50\u679c\u3001\u300cSNP\uff1ars651821\u300d\u3068\u3044\u3046\u907a\u4f1d\u5b50\u578b\u306b\u304a\u3044\u3066\u300cC\u300d\u3092\u6301\u3063\u3066\u3044\u308b\u4eba\u307b\u3069\u300c\u80a5\u6e80\u307e\u305f\u306f\u904e\u4f53\u91cd\u300d\u306e\u50be\u5411\u304c\u3042\u308a\u3001\u8840\u6db2\u4e2d\u306eHDL\uff08\u5584\u7389\uff09\u4ee5\u5916\u306e\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u6fc3\u5ea6\u3084\u4e2d\u6027\u8102\u80aa\uff08\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\uff09\u6fc3\u5ea6\u3082\u9ad8\u3044\u50be\u5411\u304c\u3042\u308b\u3068\u5206\u304b\u308a\u307e\u3057\u305f\u3002\uff08\u203b\uff09\uff08\u203b\uff09Zhu WF et al. \uff082014\uff09 “Triglyceride-raising APOA5 genetic variants are associated with obesity and non-HDL-C in Chinese children and adolescents.” Lipids Health Dis. 13:93.
\n\u305d\u3053\u3067\u3001\u672c\u8abf\u67fb\u3067\u306f\u30c0\u30a4\u30a8\u30c3\u30c8\u306e\u89b3\u70b9\u304b\u3089\u8102\u8cea\u4ee3\u8b1d\u306b\u95a2\u308f\u308b\u907a\u4f1d\u5b50\u306e\u907a\u4f1d\u5b50\u591a\u578b\u3068\u80a5\u6e80\u50be\u5411\u30fb\u4f53\u8cea\u306e\u95a2\u4fc2\u3092\u307f\u305f\u9805\u76ee\u300c\u30c0\u30a4\u30a8\u30c3\u30c8\u3010\u8102\u8cea\u4ee3\u8b1d\u3011\uff08SNP\uff1ars651821\uff09\u300d\u306b\u6ce8\u76ee\u3002
\n2023\u5e749\u6708\u306b\u540c\u30b5\u30fc\u30d3\u30b9\u306e\u5229\u7528\u8005\u306e\u4e2d\u304b\u30892\u4e071371\u4eba\u306e\u30b2\u30ce\u30e0\u30c7\u30fc\u30bf\u3092\u7528\u3044\u3066\u3001\u300c\u6a19\u6e96\u578b\u306b\u591a\u3044\u30bf\u30a4\u30d7\uff08\u907a\u4f1d\u5b50\u578b\uff1aTT\uff09\u300d\u3001\u300c\u80a5\u6e80\u578b\u306b\u591a\u304f\u8840\u4e2d\u8102\u8cea\u6fc3\u5ea6\u304c\u9ad8\u3044\u30bf\u30a4\u30d7\uff08\u907a\u4f1d\u5b50\u578b\uff1aCT\uff09\u300d\u3001\u300c\u80a5\u6e80\u578b\u306b\u591a\u304f\u8840\u4e2d\u8102\u8cea\u6fc3\u5ea6\u304c\u9ad8\u3044\u30bf\u30a4\u30d7\uff08\u907a\u4f1d\u5b50\u578b\uff1aCC\uff09\u300d\u306e3\u3064\u306e\u30bf\u30a4\u30d7\u306e\u306a\u304b\u304b\u3089\u300c\u80a5\u6e80\u578b\u306b\u591a\u304f\u8840\u4e2d\u8102\u8cea\u6fc3\u5ea6\u304c\u9ad8\u3044\u30bf\u30a4\u30d7\u300d\u3067\u3042\u308b\u300cCT\u300d\u3068\u300cCC\u300d\u306e\u907a\u4f1d\u5b50\u578b\u3092\u300c\u80a5\u6e80\u578b\u3067\u4e2d\u6027\u8102\u80aa\u304c\u9ad8\u3044\u907a\u4f1d\u5b50\u30bf\u30a4\u30d7\u300d\u3068\u3057\u3001\u8a72\u5f53\u3059\u308b\u4eba\u306e\u5272\u5408\u3092\u90fd\u9053\u5e9c\u770c\u3054\u3068\u306b\u7b97\u51fa\u3057\u3001\u6570\u5024\u5316\u3057\u307e\u3057\u305f\u3002
\n\u305d\u306e\u7d50\u679c\u3001\u300c\u80a5\u6e80\u578b\u3067\u4e2d\u6027\u8102\u80aa\u304c\u9ad8\u3044\u907a\u4f1d\u5b50\u30bf\u30a4\u30d7\u304c\u591a\u3044\u90fd\u9053\u5e9c\u770c\u300d\u306e1\u4f4d\u306f\u300c\u6c96\u7e04\u770c\u300d\uff0869.95%\uff09\u3068\u306a\u308a\u307e\u3057\u305f\u3002\u4ee5\u4e0b\u30012\u4f4d\u300c\u4f50\u8cc0\u770c\u300d\uff0863.76%\uff09\u30013\u4f4d\u300c\u9e7f\u5150\u5cf6\u770c\u300d\uff0861.99%\uff09\u30014\u4f4d\u300c\u79cb\u7530\u770c\u300d\uff0861.67%\uff09\u30015\u4f4d\u300c\u5cf6\u6839\u770c\u300d\uff0860.00%\uff09\u30016\u4f4d\u300c\u798f\u5cf6\u770c\u300d\uff0859.94%\uff09\u30017\u4f4d\u300c\u5bae\u57ce\u770c\u300d\uff0859.67%\uff09\u30018\u4f4d\u300c\u5c71\u5f62\u770c\u300d\uff0858.96%\uff09\u30019\u4f4d\u300c\u5bae\u5d0e\u770c\u300d\uff0858.94%\uff09\u300110\u4f4d\u300c\u65b0\u6f5f\u770c\u300d\uff0858.70%\uff09\u3068\u7d9a\u304d\u3001\u4e5d\u5dde\u3084\u6771\u5317\u5404\u770c\u304c\u4e0a\u4f4d\u306b\u5165\u308b\u7d50\u679c\u3068\u306a\u308a\u307e\u3057\u305f\u3002
\n\u4e00\u65b9\u3001\u300c\u80a5\u6e80\u578b\u3067\u4e2d\u6027\u8102\u80aa\u304c\u9ad8\u3044\u907a\u4f1d\u5b50\u30bf\u30a4\u30d7\u304c\u5c11\u306a\u3044\u90fd\u9053\u5e9c\u770c\u300d\u306f\u3001\u5c11\u306a\u3044\u9806\u306b\u300c\u9ad8\u77e5\u770c\u300d\uff0851.52\uff05\uff09\u3001\u300c\u9759\u5ca1\u770c\u300d\uff0852.54\uff05\uff09\u3001\u300c\u5927\u962a\u5e9c\u300d\uff0852.64\uff05\uff09\u3001\u300c\u6803\u6728\u770c\u300d\uff0852.71\uff05\uff09\u3001\u300c\u9577\u91ce\u770c\u300d\uff0852.99\uff05\uff09\u3068\u306a\u3063\u3066\u3044\u307e\u3059\u3002
\n\u306a\u304a\u3001\u6771\u4eac\u5927\u5b66\u306e\u7814\u7a76\u30c1\u30fc\u30e0\u304c2023\u5e742\u6708\u306b\u30a2\u30e1\u30ea\u30ab\u306e\u79d1\u5b66\u8a8c\u300e\u30a2\u30a4\u30b5\u30a4\u30a8\u30f3\u30b9\uff08iScience\uff09\u300f\u306e\u30aa\u30f3\u30e9\u30a4\u30f3\u7248\u3067\u767a\u8868\u3057\u305f\u7814\u7a76\u8ad6\u6587\uff08\u203b\uff09\u3067\u306f\u3001\u7e04\u6587\u4eba\u7531\u6765\u306e\u907a\u4f1d\u5b50\u591a\u578b\u3092\u591a\u304f\u6301\u3063\u3066\u3044\u308b\u300c\u201d\u7e04\u6587\u5ea6\u201d\u304c\u9ad8\u3044\u5730\u57df\u300d\u3068\u3057\u3066\u3001\u4e00\u756a\u9ad8\u3044\u306e\u306f\u300c\u6c96\u7e04\u770c\u300d\u3067\u3001\u6b21\u3044\u3067\u300c\u6771\u5317\u5404\u770c\u300d\u3084\u4e5d\u5dde\u3067\u306f\u300c\u9e7f\u5150\u5cf6\u770c\u300d\u3001\u4e2d\u56fd\u5730\u65b9\u3067\u306f\u300c\u5cf6\u6839\u770c\u300d\u3068\u5831\u544a\u3055\u308c\u3066\u304a\u308a\u3001\u672c\u8abf\u67fb\u306e\u300c\u80a5\u6e80\u578b\u3067\u4e2d\u6027\u8102\u80aa\u304c\u9ad8\u3044\u907a\u4f1d\u5b50\u30bf\u30a4\u30d7\u304c\u591a\u3044\u90fd\u9053\u5e9c\u770c\u30e9\u30f3\u30ad\u30f3\u30b0\u300d\u306e\u4e0a\u4f4d\u306b\u5165\u3063\u305f\u5730\u57df\u3068\u975e\u5e38\u306b\u4f3c\u3066\u3044\u308b\u3053\u3068\u304c\u898b\u3066\u53d6\u308c\u307e\u3057\u305f\u3002
\n\u3061\u306a\u307f\u306b\u3001\u7e04\u6587\u4eba\u7531\u6765\u306e\u907a\u4f1d\u5b50\u591a\u578b\u3067\u3042\u308b\u300c\u8840\u7cd6\u5024\u304a\u3088\u3073\u4e2d\u6027\u8102\u80aa\u3092\u9ad8\u3081\u308b\u300d\u907a\u4f1d\u7684\u56e0\u5b50\u306f\u3001\u73fe\u4ee3\u306e\u65e5\u672c\u4eba\u306b\u3068\u3063\u3066\u306f\u80a5\u6e80\u306e\u8981\u56e0\u3068\u306a\u308b\u3082\u306e\u306e\u3001\u7e04\u6587\u4eba\u306b\u3068\u3063\u3066\u306f\u3001\u8840\u7cd6\u5024\u3084\u4e2d\u6027\u8102\u80aa\u3092\u9ad8\u304f\u7dad\u6301\u3059\u308b\u3053\u3068\u3067\u5e38\u306b\u98df\u6599\u3092\u5165\u624b\u3067\u304d\u308b\u308f\u3051\u3067\u306f\u306a\u3044\u72e9\u731f\u63a1\u96c6\u751f\u6d3b\u306b\u9069\u5fdc\u3057\u3066\u3044\u305f\u53ef\u80fd\u6027\u304c\u3042\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002\uff08\u203b\uff09Watanabe, Yusuke, and Jun Ohashi. \uff082023\uff09 \u201cModern Japanese ancestry-derived variants reveal the formation process of the current Japanese regional gradations.\u201d iScience. 3;26\uff083\uff09:106130
\n\u307e\u305f\u3001\u300c\u80a5\u6e80\u578b\u306b\u591a\u304f\u8840\u4e2d\u8102\u8cea\u6fc3\u5ea6\u304c\u9ad8\u3044\u30bf\u30a4\u30d7\uff08\u907a\u4f1d\u5b50\u578b\uff1aCT\uff09\u300d\u306b\u8a72\u5f53\u3059\u308b\u65e5\u672c\u4eba\u306e\u5272\u5408\u306f45.6\uff05\u3001\u300c\u80a5\u6e80\u578b\u306b\u591a\u304f\u8840\u4e2d\u8102\u8cea\u6fc3\u5ea6\u304c\u9ad8\u3044\u30bf\u30a4\u30d7\uff08\u907a\u4f1d\u5b50\u578b\uff1aCC\uff09\u300d\u3067\u306f11.8\uff05\u3068\u306a\u3063\u305f\u3053\u3068\u304b\u3089\u3001\u65e5\u672c\u4eba\u306e\u7d046\u5272\u304c\u300c\u80a5\u6e80\u578b\u3067\u4e2d\u6027\u8102\u80aa\u304c\u9ad8\u3044\u907a\u4f1d\u5b50\u30bf\u30a4\u30d7\u300d\u306b\u8a72\u5f53\u3059\u308b\u3053\u3068\u304c\u63a8\u6e2c\u3055\u308c\u308b\u3068\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"

\u682a\u5f0f\u4f1a\u793e\u30e6\u30fc\u30b0\u30ec\u30ca\uff08\u6771\u4eac\u90fd\u6e2f\u533a\uff09\u306f\u3001\u30e6\u30fc\u30b0\u30ec\u30ca\u30fb\u30de\u30a4\u30d8\u30eb\u30b9\u3068\u30b8\u30fc\u30f3\u30af\u30a8\u30b9\u30c8\u306e\u907a\u4f1d\u5b50\u89e3\u6790\u30b5\u30fc\u30d3\u30b9\u306e\u30b2\u30ce\u30e0\u30c7\u30fc\u30bf\u3092\u3082\u3068\u306b\u3057\u305f\u3001\u300c\u80a5\u6e80\u578b\u3067\u4e2d\u6027\u8102\u80aa\u304c\u9ad8\u3044\u907a\u4f1d\u5b50\u30bf\u30a4\u30d7\u304c\u591a\u3044\u90fd\u9053\u5e9c\u770c\uff08\u51fa\u751f\u5730\uff09\u30e9\u30f3\u30ad\u30f3\u30b0\u300d\u3092\u767a\u8868\u3057\u307e\u3057\u305f\u3002 \u3010\u8868\u3011\u80a5 […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"_lmt_disableupdate":"","_lmt_disable":"","footnotes":""},"categories":[3],"tags":[2],"class_list":["post-64417","post","type-post","status-publish","format-standard","hentry","category-news","tag-2"],"modified_by":null,"_links":{"self":[{"href":"https:\/\/nihon-hanzai-jiken.com\/index.php?rest_route=\/wp\/v2\/posts\/64417","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nihon-hanzai-jiken.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/nihon-hanzai-jiken.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/nihon-hanzai-jiken.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/nihon-hanzai-jiken.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=64417"}],"version-history":[{"count":1,"href":"https:\/\/nihon-hanzai-jiken.com\/index.php?rest_route=\/wp\/v2\/posts\/64417\/revisions"}],"predecessor-version":[{"id":64418,"href":"https:\/\/nihon-hanzai-jiken.com\/index.php?rest_route=\/wp\/v2\/posts\/64417\/revisions\/64418"}],"wp:attachment":[{"href":"https:\/\/nihon-hanzai-jiken.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=64417"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/nihon-hanzai-jiken.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=64417"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/nihon-hanzai-jiken.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=64417"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}