\u203b\u672c\u7a3f\u306f\u3001\u6728\u6751\u81f3\u4fe1\u300e1\u4e07\u4eba\u306e\u9f3b\u306e\u60a9\u307f\u3092\u89e3\u6c7a\u3057\u305f\u533b\u5e2b\u304c\u6559\u3048\u308b \u9f3b\u708e\u306e\u30ea\u30bb\u30c3\u30c8\u6cd5\u300f\uff08\u30a2\u30b9\u30b3\u30e0\uff09\u306e\u4e00\u90e8\u3092\u518d\u7de8\u96c6\u3057\u305f\u3082\u306e\u3067\u3059\u3002
\n\u547c\u5438\u3068\u3057\u3066\u7406\u60f3\u306a\u306e\u306f\u3001\u300c\u53e3\u547c\u5438\u300d\u3067\u306a\u304f\u300c\u9f3b\u547c\u5438\u300d\u3067\u3059\u3002\u3086\u3063\u304f\u308a\u9f3b\u547c\u5438\u3092\u3057\u3066\u3044\u308b\u3068\u3001\u547c\u5438\u304c\u6df1\u304f\u306a\u308a\u3001\u526f\u4ea4\u611f\u795e\u7d4c\u304c\u50cd\u304d\u3084\u3059\u304f\u306a\u308a\u307e\u3059\u3002\u305d\u3046\u306a\u308c\u3070\u30b9\u30c8\u30ec\u30b9\u304c\u8efd\u6e1b\u3057\u3066\u3001\u30ea\u30e9\u30c3\u30af\u30b9\u3067\u304d\u307e\u3059\u3002\u305d\u3046\u3044\u3046\u3053\u3068\u3082\u3042\u308b\u306e\u3067\u3001\u7279\u5225\u306a\u5834\u5408\u3092\u9664\u3051\u3070\u3001\u53e3\u3067\u306f\u306a\u304f\u9f3b\u3067\u547c\u5438\u3059\u308b\u3053\u3068\u304c\u7406\u60f3\u306a\u306e\u3067\u3059\u3002
\n\u3068\u3053\u308d\u304c\u9f3b\u304c\u8a70\u307e\u3063\u305f\u308a\u9f3b\u6c34\u304c\u51fa\u305f\u308a\u3057\u3066\u3044\u308b\u3068\u3001\u606f\u304c\u5438\u3044\u306b\u304f\u3044\u306e\u3067\u53e3\u3092\u958b\u3051\u308b\u3053\u3068\u306b\u306a\u308a\u3001\u53e3\u547c\u5438\u306b\u306a\u308a\u307e\u3059\u3002\u3059\u308b\u3068\u526f\u4ea4\u611f\u795e\u7d4c\u304c\u50cd\u304d\u306b\u304f\u304f\u306a\u308a\u307e\u3059\u3002
\n\u3055\u3089\u306b\u3001\u53e3\u547c\u5438\u3092\u3057\u3066\u3044\u308b\u3068\u3001\u30a6\u30a4\u30eb\u30b9\u304c\u9f3b\u6bdb\u3068\u3044\u3046\u30d5\u30a3\u30eb\u30bf\u30fc\u3067\u906e\u3089\u308c\u308b\u3053\u3068\u306a\u304f\u4f53\u5185\u306b\u53d6\u308a\u8fbc\u307e\u308c\u3066\u3057\u307e\u3046\u306e\u3067\u3001\u98a8\u90aa\u3092\u5f15\u304d\u3084\u3059\u304f\u306a\u308a\u307e\u3059\u3002
\n\u307e\u305f\u3001\u7a7a\u6c17\u304c\u53e3\u306e\u4e2d\u3092\u901a\u308b\u306e\u3067\u3001\u30c9\u30e9\u30a4\u30de\u30a6\u30b9\u306b\u3082\u306a\u308a\u307e\u3059\u3002\u53e3\u304c\u4e7e\u3044\u305f\u72b6\u614b\u3067\u3059\u3002\u53e3\u304c\u4e7e\u3044\u3066\u553e\u6db2\u304c\u6e1b\u308c\u3070\u3001\u866b\u6b6f\u3084\u6b6f\u5468\u75c5\u306b\u306a\u308a\u307e\u3059\u3002\u53e3\u306e\u4e2d\u306b\u96d1\u83cc\u304c\u5e83\u304c\u308b\u306e\u3067\u3001\u53e3\u81ed\u3082\u51fa\u307e\u3059\u3002\u305d\u306e\u96d1\u83cc\u304c\u4f53\u306e\u5965\u306b\u5165\u308c\u3070\u3001\u80ba\u708e\u3084\u5fc3\u7b4b\u6897\u585e\u306e\u539f\u56e0\u306b\u3082\u306a\u308a\u307e\u3059\u3002
\n\u3044\u3064\u3082\u9f3b\u3092\u8a70\u307e\u3089\u305b\u305f\u308a\u3059\u3059\u3063\u305f\u308a\u3057\u3066\u3044\u308b\u3068\u3001\u4e2d\u8033\u708e\u306b\u306a\u308b\u53ef\u80fd\u6027\u304c\u9ad8\u304f\u306a\u308a\u307e\u3059\u3002\u9f3b\u3068\u8033\u306f\u300c\u8033\u7ba1\u300d\u3068\u3044\u3046\u7d30\u3044\u30d1\u30a4\u30d7\u3067\u3064\u306a\u304c\u3063\u3066\u3044\u3066\u3001\u305d\u3053\u3092\u7a7a\u6c17\u304c\u901a\u3063\u3066\u3044\u307e\u3059\u3002\u9f3b\u306e\u4e2d\u3067\u708e\u75c7\u304c\u8d77\u304d\u305f\u308a\u7c98\u6db2\u304c\u5897\u3048\u305f\u308a\u3059\u308b\u3068\u3001\u305d\u306e\u305b\u3044\u3067\u8033\u7ba1\u304c\u8a70\u307e\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002
\n\u8033\u7ba1\u306e\u4e2d\u306e\u7a7a\u6c17\u304c\u5c11\u306a\u304f\u306a\u308b\u3068\u3001\u9f13\u819c\u306e\u5965\u306b\u6db2\u304c\u6e9c\u307e\u3063\u305f\u308a\u3001\u7d30\u83cc\u304c\u5165\u308a\u3084\u3059\u304f\u306a\u3063\u305f\u308a\u3057\u3066\u3001\u4e2d\u8033\u708e\u306b\u306a\u308b\u306e\u3067\u3059\u3002\u7279\u306b\u3001\u307e\u3060\u8033\u7ba1\u304c\u77ed\u3044\u5b50\u3069\u3082\u306f\u3001\u4e2d\u8033\u708e\u306b\u306a\u308a\u3084\u3059\u304f\u306a\u308a\u307e\u3059\u3002
\n\u9577\u5f15\u304f\u9f3b\u3065\u307e\u308a\u3092\u307b\u3046\u3063\u3066\u304a\u304f\u3068\u3001\u3081\u307e\u3044\u3001\u96e3\u8074\u3001\u8033\u9cf4\u308a\u306b\u306a\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002\u9f3b\u3065\u307e\u308a\u306e\u305b\u3044\u3067\u8033\u7ba1\u304c\u3046\u307e\u304f\u958b\u304b\u306a\u304f\u306a\u3063\u305f\u3053\u3068\u304c\u539f\u56e0\u3067\u3059\u3002
\n\u5c0f\u5b66\u751f\u304f\u3089\u3044\u307e\u3067\u306e\u304a\u5b50\u3055\u3093\u306f\u3001\u9f3b\u306e\u5965\u3067\u300c\u30a2\u30c7\u30ce\u30a4\u30c9\u300d\u3068\u3044\u3046\u30ea\u30f3\u30d1\u7d44\u7e54\u304c\u5927\u304d\u304f\u306a\u3063\u3066\u3044\u304f\u305f\u3081\u3001\u84c4\u81bf\u75c7\u306b\u306a\u308a\u3084\u3059\u304f\u3001\u7d50\u679c\u3001\u8133\u306b\u9178\u7d20\u304c\u5c4a\u304f\u306e\u3092\u90aa\u9b54\u3059\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002\u305d\u306e\u305b\u3044\u3067\u6210\u7e3e\u304c\u843d\u3061\u305f\u308a\u3001\u300c\u30a2\u30c7\u30ce\u30a4\u30c9\u9854\u8c8c(\u304c\u3093\u307c\u3046)\u300d\u3068\u3044\u3046\u72ec\u7279\u306e\u9854\u3064\u304d\u306b\u306a\u3063\u305f\u308a\u3001\u96e3\u8074\u306b\u306a\u3063\u305f\u308a\u3001\u591c\u5c3f\u75c7\u306b\u306a\u3063\u305f\u308a\u3059\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002\u30a2\u30c7\u30ce\u30a4\u30c9\u306f\u8ab0\u3067\u3082\u6301\u3063\u3066\u3044\u308b\u7d44\u7e54\u3067\u3059\u304c\u3001\u3072\u3069\u3044\u5834\u5408\u306b\u306f\u624b\u8853\u3067\u53d6\u308a\u9664\u304b\u306a\u304f\u3066\u306f\u306a\u308a\u307e\u305b\u3093\u3002
\n\u9f3b\u3065\u307e\u308a\u304c\u7d9a\u304f\u65b9\u306f\u8033\u9f3b\u79d1\u306e\u30af\u30ea\u30cb\u30c3\u30af\u306b\u884c\u3063\u3066\u3001\u539f\u56e0\u306b\u306a\u308b\u75c5\u6c17\u3092\u7279\u5b9a\u3057\u3066\u3082\u3089\u3044\u307e\u3057\u3087\u3046\u3002\u300c\u305f\u304b\u304c\u9f3b\u3065\u307e\u308a\u300d\u3068\u8efd\u8996\u3059\u308b\u306e\u306f\u5371\u967a\u3067\u3059\u3002
\n\u9f3b\u304c\u60aa\u3051\u308c\u3070\u55c5\u899a\u304c\u843d\u3061\u3001\u305d\u308c\u306f\u8a8d\u77e5\u75c7\u306e\u5371\u967a\u56e0\u5b50\u306b\u306a\u308a\u307e\u3059\u3002\u306a\u305c\u306a\u3089\u3001\u55c5\u899a\u3092\u53f8\u308b\u8133\u306e\u90e8\u4f4d\u306f\u3001\u8a18\u61b6\u3084\u611f\u60c5\u3092\u53f8\u308b\u6d77\u99ac\u3084\u6241\u6843\u4f53\u306a\u3069\u3068\u5bc6\u63a5\u306b\u9023\u643a\u3057\u3066\u3044\u308b\u304b\u3089\u3067\u3059\u3002\u307e\u305f\u3001\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u3067\u8133\u306b\u84c4\u7a4d\u3059\u308b\u7570\u5e38\u30bf\u30f3\u30d1\u30af\u8cea\uff08\u30a2\u30df\u30ed\u30a4\u30c9\u306a\u3069\uff09\u306f\u3001\u55c5\u899a\u3092\u51e6\u7406\u3059\u308b\u8133\u306e\u9818\u57df\u3067\u65e9\u3044\u6642\u671f\u304b\u3089\u898b\u3064\u304b\u308a\u307e\u3059\u3002\u3064\u307e\u308a\u3001\u9f3b\u304c\u60aa\u3044\u3068\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306b\u306a\u308b\u53ef\u80fd\u6027\u304c\u9ad8\u307e\u308b\u306e\u3067\u3059\u3002
\n\u307e\u305f\u3001\u84c4\u81bf\u75c7\uff08\u6162\u6027\u526f\u9f3b\u8154\u708e\uff09\u304c\u3042\u308b\u3068\u3001\u4f53\u5185\u3067\u708e\u75c7\u7269\u8cea\uff08\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\uff09\u304c\u5897\u3048\u307e\u3059\u3002\u305d\u308c\u304c\u8840\u6db2\u3092\u4ecb\u3057\u3066\u8133\u306b\u5c4a\u304f\u3068\u3001\u8133\u795e\u7d4c\u306b\u708e\u75c7\u304c\u8d77\u304d\u3066\u3001\u8a8d\u77e5\u6a5f\u80fd\u304c\u4f4e\u4e0b\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002
\n\u3055\u3089\u306b\u3001\u9f3b\u304c\u60aa\u3044\u3068\u7761\u7720\u6642\u7121\u547c\u5438\u75c7\u5019\u7fa4\u3084\u3001\u7761\u7720\u306e\u8cea\u306e\u4f4e\u4e0b\u304c\u5371\u3076\u307e\u308c\u307e\u3059\u3002\u7761\u7720\u4e0d\u8db3\u306b\u306a\u308c\u3070\u3001\u8133\u7d30\u80de\u306e\u6d3b\u6027\u5316\u304c\u505c\u6ede\u3057\u3066\u3001\u3084\u306f\u308a\u8a8d\u77e5\u6a5f\u80fd\u304c\u843d\u3061\u308b\u3053\u3068\u306b\u306a\u308a\u307e\u3059\u3002\u9f3b\u304c\u60aa\u3044\u3053\u3068\u3067\u8a8d\u77e5\u75c7\u306b\u306a\u308b\u53ef\u80fd\u6027\u306f\u3001\u3051\u3063\u3057\u3066\u5426\u5b9a\u3067\u304d\u306a\u3044\u306e\u3067\u3059\u3002
\n\u9f3b\u708e\u306f\u300c\u58f0\u304c\u51fa\u3057\u306b\u304f\u3044\u300d\u300c\u58f0\u304c\u304b\u3059\u308c\u308b\u300d\u306a\u3069\u306e\u767a\u58f0\u969c\u5bb3\u3068\u3001\u76f4\u63a5\u7684\u306a\u95a2\u4fc2\u304c\u3042\u308b\u308f\u3051\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002\u3051\u308c\u3069\u3082\u3001\u9593\u63a5\u7684\u306b\u306f\u58f0\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002
\n\u9f3b\u304c\u8a70\u307e\u308b\u3068\u3001\u9593\u9055\u3044\u306a\u304f\u58f0\u306e\u300c\u97ff\u304d\u300d\u306b\u5f71\u97ff\u3057\u307e\u3059\u3002\u982d\u84cb\u9aa8\u306e\u4e2d\u3067\u3001\u58f0\u304c\u5171\u9cf4\u3059\u308b\u7a7a\u9593\u304c\u585e\u304c\u308c\u3066\u3057\u307e\u3046\u304b\u3089\u3067\u3059\u3002\u305d\u306e\u7d50\u679c\u3001\u58f0\u304c\u3053\u3082\u3063\u305f\u308a\u3001\u9f3b\u58f0\u306b\u306a\u3063\u305f\u308a\u3057\u307e\u3059\u3002\u58f0\u5e2f\u306e\u52d5\u304d\u306b\u554f\u984c\u304c\u3042\u308b\u308f\u3051\u3067\u306f\u306a\u3044\u306e\u3067\u3001\u53b3\u5bc6\u306b\u306f\u300c\u767a\u58f0\u969c\u5bb3\u300d\u3068\u306f\u3044\u3048\u307e\u305b\u3093\u304c\u3001\u58f0\u306e\u8cea\u304c\u5909\u308f\u308b\u3053\u3068\u306b\u306f\u9055\u3044\u3042\u308a\u307e\u305b\u3093\u3002
\n\u307e\u305f\u3001\u9f3b\u6c34\u304c\u5589\u306e\u307b\u3046\u306b\u6d41\u308c\u843d\u3061\u308b\u300c\u5f8c\u9f3b\u6f0f(\u3053\u3046\u3073\u308d\u3046)\u300d\u304c\u3042\u308b\u3068\u3001\u305d\u308c\u304c\u5589\u306e\u7c98\u819c\u3084\u58f0\u5e2f\u3092\u523a\u6fc0\u3057\u3001\u6162\u6027\u7684\u306a\u708e\u75c7\u3084\u54b3\u3092\u8a98\u767a\u3057\u307e\u3059\u3002\u305d\u308c\u304c\u7e70\u308a\u8fd4\u3055\u308c\u308b\u3068\u3001\u58f0\u5e2f\u306b\u8ca0\u62c5\u304c\u304b\u304b\u308a\u3001\u58f0\u304c\u304b\u3059\u308c\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002
\n\u3055\u3089\u306b\u3001\u9f3b\u304c\u60aa\u3044\u305b\u3044\u3067\u53e3\u547c\u5438\u3092\u3057\u3066\u3044\u308b\u3068\u3001\u5589\u3084\u58f0\u5e2f\u306e\u7c98\u819c\u306e\u6f64\u6ed1\u6027\u304c\u5931\u308f\u308c\u3001\u305d\u306e\u305b\u3044\u3067\u58f0\u304c\u51fa\u3057\u306b\u304f\u304f\u306a\u308a\u307e\u3059\u3002\u4e7e\u71e5\u3057\u305f\u58f0\u5e2f\u306f\u50b7\u3064\u304d\u3084\u3059\u304f\u3001\u8efd\u3044\u708e\u75c7\u3092\u8d77\u3053\u3057\u307e\u3059\u3002\u58f0\u5e2f\u306e\u708e\u75c7\u304c\u9577\u5f15\u3044\u305f\u308a\u7e70\u308a\u8fd4\u3055\u308c\u305f\u308a\u3059\u308b\u3068\u3001\u30dd\u30ea\u30fc\u30d7\u306a\u3069\u306e\u30ea\u30b9\u30af\u3092\u9ad8\u3081\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u9f3b\u3092\u5065\u5eb7\u306b\u3057\u3066\u3001\u6df1\u523b\u306a\u75c5\u6c17\u306e\u30ea\u30b9\u30af\u3092\u9060\u3056\u3051\u307e\u3057\u3087\u3046\u3002
\n\u304f\u3057\u3083\u307f\u3001\u9f3b\u6c34\u3001\u9f3b\u3065\u307e\u308a\u306a\u3069\u306e\u75c7\u72b6\u304c\u3042\u308b\u5834\u5408\u300170\u4ee3\u4ee5\u4e0a\u306e\u65b9\u3067\u3042\u308c\u3070\u300c\u904e\u654f\u6027\u9f3b\u708e\uff08\u8840\u7ba1\u904b\u52d5\u6027\u9f3b\u708e\uff09\u300d\u3067\u3042\u308b\u53ef\u80fd\u6027\u304c\u9ad8\u3044\u3067\u3057\u3087\u3046\u3002\u904e\u654f\u6027\u9f3b\u708e\u306e\u539f\u56e0\u306f\u3001\u6e29\u5ea6\u5dee\u3001\u6e7f\u5ea6\u3001\u5316\u5b66\u7269\u8cea\u3001\u81ed\u3044\u306a\u3069\u3044\u308d\u3044\u308d\u3067\u3059\u3002\u3053\u306e\u3088\u3046\u306a\u539f\u56e0\u306b\u9f3b\u306e\u7c98\u819c\u304c\u904e\u654f\u306b\u53cd\u5fdc\u3057\u3066\u3001\u9f3b\u708e\u306e\u75c7\u72b6\u304c\u8d77\u3053\u308a\u307e\u3059\u3002
\n\u30a2\u30ec\u30eb\u30ae\u30fc\u6027\u9f3b\u708e\u3068\u75c7\u72b6\u304c\u4f3c\u3066\u3044\u307e\u3059\u304c\u3001\u30a2\u30ec\u30eb\u30b2\u30f3\u3084\u514d\u75ab\u53cd\u5fdc\u306f\u95a2\u4e0e\u3057\u306a\u3044\u306e\u3067\u3001IgE\u6297\u4f53\u306a\u3069\u306e\u691c\u67fb\u3092\u3057\u3066\u3082\u3001\u7570\u5e38\u304c\u8a8d\u3081\u3089\u308c\u307e\u305b\u3093\u3002\u75c7\u72b6\u3084\u8a98\u56e0\u304b\u3089\u300c\u904e\u654f\u6027\u9f3b\u708e\u300d\u3060\u3068\u8a3a\u65ad\u3055\u308c\u308b\u3053\u3068\u306b\u306a\u308a\u307e\u3059\u3002
\n\u305f\u3060\u3001\u300c\u30a2\u30ec\u30eb\u30b2\u30f3\uff08\u30a2\u30ec\u30eb\u30ae\u30fc\u53cd\u5fdc\u3092\u8d77\u3053\u3059\u7269\u8cea\uff09\u3092\u9060\u3056\u3051\u308b\u300d\u3068\u3044\u3046\u3053\u3068\u4ee5\u5916\u306f\u3001\u30a2\u30ec\u30eb\u30ae\u30fc\u6027\u9f3b\u708e\u3068\u300c\u904e\u654f\u6027\u9f3b\u708e\u300d\u306e\u5bfe\u51e6\u6cd5\u306f\u540c\u3058\u3067\u3059\u3002
\n\u307e\u305f\u3001\u9ad8\u9f62\u306b\u306a\u3063\u3066\u304b\u3089\u3001\u7c98\u308a\u6c17\u306e\u3042\u308b\u9f3b\u6c34\u304c\u6b62\u307e\u3089\u306a\u304f\u3066\u30c6\u30a3\u30c3\u30b7\u30e5\u304c\u624b\u653e\u305b\u306a\u304f\u306a\u3063\u305f\u65b9\u306f\u3001\u300c\u526f\u9f3b\u8154\u708e\u300d\u3067\u3042\u308b\u53ef\u80fd\u6027\u304c\u9ad8\u3044\u3068\u601d\u3044\u307e\u3059\u3002\u305d\u308c\u306f\u3001\u304a\u5e74\u3092\u53ec\u3059\u3068\u98a8\u90aa\u3092\u5f15\u304d\u3084\u3059\u304f\u306a\u308b\u3053\u3068\u3068\u95a2\u4fc2\u304c\u3042\u308a\u307e\u3059\u3002\u52a0\u9f62\u304c\u539f\u56e0\u3067\u526f\u9f3b\u8154\u708e\u306b\u304b\u304b\u308b\u4eba\u306f\u3044\u307e\u305b\u3093\u304c\u3001\u98a8\u90aa\u304c\u9060\u56e0\u306b\u306a\u3063\u3066\u526f\u9f3b\u8154\u708e\u306b\u304b\u304b\u308b\u65b9\u306f\u3044\u308b\u306e\u3067\u3059\u3002
\n\u9f62(\u3088\u308f\u3044)\u3092\u91cd\u306d\u308b\u3068\u3001\u9f3b\u306e\u7c98\u819c\u304c\u5f31\u3063\u3066\u3044\u304d\u307e\u3059\u3002\u307e\u305f\u3001\u9f3b\u3092\u304b\u3080\u529b\u3082\u5f31\u3063\u3066\u3044\u304d\u307e\u3059\u3002\u305d\u3046\u306a\u308b\u3068\u3001\u9f3b\u6c34\u304c\u51fa\u3084\u3059\u304f\u3001\u98a8\u90aa\u3082\u5f15\u304d\u3084\u3059\u304f\u306a\u308a\u307e\u3059\u3002\u305d\u306e\u98a8\u90aa\u304c\u9577\u5f15\u304f\u3068\u3001\u526f\u9f3b\u8154\u708e\u306b\u306a\u308a\u3084\u3059\u304f\u306a\u308b\u306e\u3067\u3059\u3002\u5e74\u4ee3\u3092\u554f\u308f\u305a\u526f\u9f3b\u8154\u708e\u306f\u6cbb\u308a\u306b\u304f\u3044\u306e\u3067\u3059\u304c\u3001\u7279\u306b\u304a\u5e74\u3092\u53ec\u3057\u305f\u65b9\u306e\u300c\u526f\u9f3b\u8154\u708e\u300d\u306f\u6162\u6027\u5316\u30fb\u91cd\u75c7\u5316\u3057\u3084\u3059\u3044\u306e\u3067\u3001\u8efd\u8996\u3067\u304d\u307e\u305b\u3093\u3002\u3067\u3059\u304b\u3089\u3001\u307e\u305a\u306f\u9f3b\u98a8\u90aa\u3092\u9577\u5f15\u304b\u305b\u306a\u3044\u3053\u3068\u304c\u809d\u8981\u3067\u3059\u3002
\n\u526f\u9f3b\u8154\u708e\u306b\u306a\u308c\u3070\u3001\u5302\u3044\u304c\u308f\u304b\u308a\u306b\u304f\u304f\u306a\u308a\u307e\u3059\u3002\u5302\u3044\u306f\u8133\u306e\u6d3b\u6027\u5316\u306b\u5bc4\u4e0e\u3057\u3066\u3044\u307e\u3059\u3002\u9006\u304b\u3089\u8a00\u3048\u3070\u3001\u55c5\u899a\u3092\u920d\u3044\u307e\u307e\u653e\u7f6e\u3057\u3066\u304a\u304f\u3068\u3001\u8a8d\u77e5\u75c7\u306e\u767a\u75c7\u3084\u60aa\u5316\u306b\u3064\u306a\u304c\u308a\u307e\u3059\u3002\u307e\u305f\u3001\u5302\u3044\u304c\u308f\u304b\u308a\u306b\u304f\u3051\u308c\u3070\u98df\u3079\u308b\u697d\u3057\u307f\u3082\u6e1b\u3063\u3066\u3057\u307e\u3044\u3001\u3053\u308c\u307e\u305f\u8133\u306e\u6d3b\u6027\u5316\u3092\u5f31\u3081\u3066\u3057\u307e\u3044\u307e\u3059\u3002
\n\u3064\u307e\u308a\u3001\u55c5\u899a\u304c\u843d\u3061\u308b\u3053\u3068\u306f\u3001\u8a8d\u77e5\u75c7\u306e\u30b5\u30a4\u30f3\u3067\u3082\u3042\u308b\u3068\u3044\u3046\u3053\u3068\u3002\u526f\u9f3b\u8154\u708e\u304c\u3042\u3063\u3066\u55c5\u899a\u304c\u843d\u3061\u3066\u3044\u308b\u306a\u3089\u3001\u526f\u9f3b\u8154\u708e\u3092\u6cbb\u3057\u3066\u55c5\u899a\u3092\u623b\u3059\u3053\u3068\u304c\u8a8d\u77e5\u75c7\u306e\u4e88\u9632\u306b\u306a\u308a\u307e\u3059\u3002\u55c5\u899a\u306b\u9650\u3089\u305a\u3001\u304a\u5e74\u3092\u53ec\u3057\u305f\u65b9\u304c\u9f3b\u708e\u3092\u653e\u7f6e\u3057\u3066\u304a\u304f\u3068\u3001\u8074\u899a\u3084\u5473\u899a\u306e\u60aa\u5316\u304c\u82e5\u3044\u4eba\u4ee5\u4e0a\u306b\u52a0\u901f\u3057\u307e\u3059\u3002
\n\u306a\u306b\u3088\u308a\u5fc3\u914d\u306a\u306e\u306f\u3001\u6162\u6027\u306b\u306a\u3063\u305f\u526f\u9f3b\u8154\u708e\u304c\u300c\u9ac4\u819c\u708e\u300d\u3092\u62db\u304f\u3053\u3068\u3002\u9ac4\u819c\u708e\u306f\u8133\u3068\u810a\u9ac4\u3092\u8986\u3046\u9ac4\u819c\u306b\u7d30\u83cc\u3084\u30a6\u30a4\u30eb\u30b9\u306a\u3069\u304c\u611f\u67d3\u3057\u3001\u708e\u75c7\u304c\u8d77\u3053\u308b\u75c5\u6c17\u3067\u3059\u3002
\n\u307e\u305f\u3001\u9f3b\u306e\u4e2d\u306e\u7c98\u819c\u304c\u5f31\u307e\u308b\u3068\u3001\u526f\u9f3b\u8154\u708e\u306e\u83cc\u304c\u9f3b\u306e\u4e2d\u306b\u6b8b\u308a\u3084\u3059\u304f\u3001\u305d\u306e\u83cc\u304c\u5168\u8eab\u306b\u56de\u3063\u3066\u300c\u6557\u8840\u75c7\u300d\u3084\u300c\u80ba\u708e\u300d\u306b\u306a\u308a\u3001\u526f\u9f3b\u8154\u708e\u3082\u91cd\u75c7\u5316\u3057\u307e\u3059\u3002\u6557\u8840\u75c7\u3068\u306f\u3001\u7d30\u83cc\u3084\u30a6\u30a4\u30eb\u30b9\u306a\u3069\u306e\u611f\u67d3\u75c7\u304c\u5f15\u304d\u91d1\u306b\u306a\u3063\u3066\u5236\u5fa1\u4e0d\u80fd\u306a\u708e\u75c7\u304c\u8d77\u3053\u308a\u3001\u5fc3\u81d3\u3001\u80ba\u3001\u814e\u81d3\u306a\u3069\u304c\u969c\u5bb3\u3055\u308c\u308b\u3001\u751f\u547d\u306b\u95a2\u308f\u308b\u72b6\u614b\u3067\u3059\u3002
\n\u526f\u9f3b\u8154\u708e\u304c\u3053\u3058\u308c\u3066\u9ac4\u819c\u708e\u3084\u6557\u8840\u75c7\u306b\u306a\u308a\u3001\u547d\u3092\u843d\u3068\u3055\u308c\u308b\u9ad8\u9f62\u8005\u306f\u3001\u5e74\u9593\u306b100\u4eba\u3050\u3089\u3044\u3044\u307e\u3059\u3002\u526f\u9f3b\u8154\u708e\u3092\u65e9\u3081\u306b\u6cbb\u7642\u3059\u308c\u3070\u3001\u9ac4\u819c\u708e\u3084\u6557\u8840\u75c7\u3092\u4f75\u767a\u3055\u305b\u308b\u5371\u967a\u6027\u3092\u4f4e\u3081\u3001\u8a8d\u77e5\u75c7\u306e\u767a\u75c7\u3084\u4e88\u9632\u3092\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002
\n\u5df7\u3067\u306f\u300c\u52a0\u9f62\u6027\u9f3b\u708e\u300d\u3068\u3044\u3046\u8a00\u8449\u304c\u306f\u3084\u3063\u3066\u3044\u308b\u3088\u3046\u3067\u3059\u3002\u3067\u3059\u304c\u3001\u300c\u52a0\u9f62\u6027\u9f3b\u708e\u300d\u3068\u3044\u3046\u6b63\u5f0f\u306a\u75c5\u540d\u306f\u306a\u3044\u3057\u3001\u305d\u306e\u8a00\u8449\u3092\u4f7f\u3046\u8033\u9f3b\u79d1\u533b\u3082\u3042\u307e\u308a\u3044\u307e\u305b\u3093\u3002\u305d\u308c\u306f\u3001\u52a0\u9f62\u304c\u539f\u56e0\u3067\u8d77\u3053\u308b\u9f3b\u708e\u306a\u3069\u306a\u3044\u304b\u3089\u3067\u3059\u3002
\n\u306a\u306b\u3052\u306a\u3044\u4f1a\u8a71\u3067\u3001\u304a\u5e74\u3092\u53ec\u3057\u305f\u65b9\u304c\u300c\u85ac\u306f\u52b9\u304b\u306a\u3044\u3057\u3001\u6c34\u306e\u3088\u3046\u306a\u9f3b\u6c34\u304c\u6b62\u307e\u3089\u306a\u3044\u300d\u3068\u8a00\u3063\u305f\u3068\u304d\u3001\u300c\u305d\u308c\u3001\u52a0\u9f62\u6027\u9f3b\u708e\u304b\u3082\u3057\u308c\u306a\u3044\u300d\u3068\u304a\u3063\u3057\u3083\u308b\u65b9\u304c\u3044\u308b\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u304c\u3001\u300c\u305d\u3046\u306a\u306e\u304b\u300d\u3068\u7d0d\u5f97\u306a\u3055\u3089\u306a\u3044\u3067\u304f\u3060\u3055\u3044\u3002
\n\u305d\u3046\u3044\u3046\u75c7\u72b6\u306e\u307b\u3068\u3093\u3069\u306f\u3001\u300c\u30a2\u30ec\u30eb\u30ae\u30fc\u6027\u9f3b\u708e\u300d\u304b\u300c\u526f\u9f3b\u8154\u708e\u300d\u3001\u307e\u305f\u306f\u300c\u904e\u654f\u6027\u9f3b\u708e\uff08\u8840\u7ba1\u904b\u52d5\u6027\u9f3b\u708e\uff09\u300d\u3067\u3059\u3002
\n\u540c\u3058\u3088\u3046\u306b\u3001\u300c\u5e74\u3092\u3068\u308b\u3068\u30c9\u30e9\u30a4\u30ce\u30fc\u30ba\u306b\u306a\u308a\u3084\u3059\u3044\u300d\u3068\u601d\u3044\u8fbc\u3093\u3067\u3044\u308b\u65b9\u3082\u3044\u3089\u3063\u3057\u3083\u3044\u307e\u3059\u304c\u3001\u5b9f\u306f\u300c\u30c9\u30e9\u30a4\u30ce\u30fc\u30ba\u300d\u306f\u75c5\u540d\u3067\u306f\u306a\u304f\u3001\u5358\u306a\u308b\u75c7\u72b6\u3067\u3059\u3002
\n\u773c\u304c\u4e7e\u304f\u300c\u30c9\u30e9\u30a4\u30a2\u30a4\u300d\u3084\u3001\u53e3\u304c\u4e7e\u304f\u300c\u30c9\u30e9\u30a4\u30de\u30a6\u30b9\u300d\uff08\u6b63\u5f0f\u306b\u306f\u300c\u53e3\u8154\u4e7e\u71e5\u75c7\u300d\uff09\u3068\u3044\u3046\u75c5\u6c17\u306f\u5b58\u5728\u3057\u3001\u305d\u308c\u305e\u308c\u306b\u5bfe\u5fdc\u3059\u308b\u85ac\u3082\u3042\u308a\u307e\u3059\u3002\u3067\u3059\u304c\u3001\u30c9\u30e9\u30a4\u30ce\u30fc\u30ba\u3068\u3044\u3046\u75c5\u6c17\u306f\u306a\u304f\u3001\u4f55\u304b\u306e\u75c5\u6c17\u3067\u305d\u306e\u75c7\u72b6\u304c\u51fa\u3066\u3044\u308b\u306e\u3067\u3059\u3002\u305d\u306e\u591a\u304f\u306f\u300c\u30a2\u30ec\u30eb\u30ae\u30fc\u6027\u9f3b\u708e\u300d\u3067\u3059\u3002
\n\u3082\u3061\u308d\u3093\u3001\u9f3b\u306e\u4e2d\u304c\u4e7e\u71e5\u3057\u3066\u7c98\u819c\u304c\u30d2\u30ea\u30d2\u30ea\u75db\u3093\u3060\u308a\u9f3b\u8840\u304c\u51fa\u305f\u308a\u3059\u308b\u3053\u3068\u306f\u3042\u308a\u307e\u3059\u3002\u3067\u3059\u304c\u3001\u9f3b\u306e\u7c98\u819c\u3060\u3051\u304c\u4e7e\u71e5\u3059\u308b\u3053\u3068\u306f\u3042\u308a\u3048\u307e\u305b\u3093\u3002\u9f62\u3092\u91cd\u306d\u308b\u3068\u4f53\u4e2d\u306e\u3059\u3079\u3066\u306e\u7c98\u6db2\u304c\u5c11\u306a\u304f\u306a\u308a\u3001\u3059\u3079\u3066\u306e\u7c98\u819c\u304c\u4e7e\u71e5\u3059\u308b\u306e\u3067\u3059\u3002
\n\u9f3b\u306e\u4e7e\u71e5\u3092\u8a34\u3048\u308b\u65b9\u306b\u306f\u3001\u79c1\u306f\u300c\u9f3b\u307b\u3063\u3068\u30bf\u30aa\u30eb\u300d\u3092\u3084\u3063\u3066\u3044\u305f\u3060\u304d\u307e\u3059\u3002
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\n\uff083\uff09\u4e0a\u304b\u3089\u526f\u9f3b\u8154\u306e\u30c4\u30dc\u3092\u62bc\u305b\u3070\u3001\u3088\u308a\u4e0d\u5feb\u611f\u304c\u843d\u3061\u7740\u304d\u307e\u3059\u3002
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\n\uff08\u53c2\u8003\u6587\u732e\uff09\u30fb\u74b0\u5883\u7701,\u300c\u82b1\u7c89\u75c7\u4fdd\u5065\u6307\u5c0e\u30de\u30cb\u30e5\u30a2\u30eb\u300d\u30fb\u6589\u85e4\u6d0b\u4e09\u30fb\u4e95\u624b\u6b66\u300c\u82b1\u7c89\u75c7\u306e\u79d1\u5b66\u300d\uff08\u5316\u5b66\u540c\u4eba\u51fa\u7248\uff09\u30fb\u6589\u85e4\u6d0b\u4e09\u30fb\u4e95\u624b\u6b66\u30fb\u6751\u5c71\u8ca2\u53f8\u300c\u65b0\u7de8 \u82b1\u7c89\u75c7\u306e\u79d1\u5b66\u300d\uff08\u5316\u5b66\u540c\u4eba\u51fa\u7248\uff09\u30fb\u4eca\u4e95\u900f\u300c\u540d\u533b\u306e\u308f\u304b\u308a\u3084\u3059\u3044\u82b1\u7c89\u75c7\u30fb\u30a2\u30ec\u30eb\u30ad\u30fc\u6027\u9f3b\u708e\u300d\uff08\u540c\u6587\u66f8\u9662\u51fa\u7248\uff09\u30fb\u6771\u4eac\u79d1\u5b66\u5927\u5b66 \u203b\u5927\u5b66\u9662\u533b\u6b6f\u5b66\u7dcf\u5408\u7814\u7a76\u79d1 \u8a8d\u77e5\u795e\u7d4c\u751f\u7269\u5b66\u5206\u91ce \u4e0a\u962a\u76f4\u53f2\u6559\u6388\u3068\u54ac\u5408\u6a5f\u80fd\u77ef\u6b63\u5b66\u5206\u91ce \u5c0f\u91ce\u5353\u53f2\u6559\u6388\u306e\u7814\u7a76\u30b0\u30eb\u30fc\u30d7 Communications biology 2024 Oct 23;7(1):1381.\u300cNasal obstruction during development leads to defective synapse elimination, hypersynchrony, and impaired cerebellar function\u300dMoe Tanigawa, Mengke Liu, Mariko Sekiguchi, Kyosuke Goda, Chiho Kato, Takashi Ono and Naofumi Uesaka DOI:10.1038\/s42003-024-07095-4
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