\u4eca\u3084\u65e5\u672c\u4eba\u306e2\u4eba\u306b1\u4eba\u304c\u30b9\u30ae\u82b1\u7c89\u75c7\u3060\u3068\u3044\u308f\u308c\u3066\u3044\u307e\u3059\u3002\u82b1\u7c89\u98db\u6563\u91cf\u306e\u5897\u52a0\u306b\u3088\u308a\u3001\u4ee5\u524d\u3088\u308a\u3082\u5b50\u3069\u3082\u3084\u82e5\u5e74\u5c64\u306e\u767a\u75c7\u8005\u304c\u5897\u52a0\u3059\u308b\u4e00\u65b9\u3001\u9ad8\u9f62\u3067\u767a\u75c7\u3059\u308b\u30b1\u30fc\u30b9\u3082\u3042\u308b\u306e\u3067\u82e5\u304f\u306a\u3044\u304b\u3089\u5927\u4e08\u592b\u3068\u3044\u3046\u308f\u3051\u3067\u3082\u3042\u308a\u307e\u305b\u3093\u3002\u79c1\u81ea\u8eab\u3082\u82b1\u7c89\u75c7\u3067\u3001\u6bce\u5e74\u3001\u9f3b\u6c34\u3084\u76ee\u306e\u304b\u3086\u307f\u306b\u60a9\u307e\u3055\u308c\u3066\u3044\u3066\u3001\u307e\u3063\u305f\u304f\u4ed6\u4eba\u4e8b\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002
\n\u3055\u3066\u3001\u82b1\u7c89\u75c7\u306e\u30b1\u30a2\u3067\u3082\u3063\u3068\u3082\u5927\u5207\u306a\u306e\u306f\u3001\u65e9\u3081\u306b\u6cbb\u7642\u3092\u958b\u59cb\u3059\u308b\u3053\u3068\u3067\u3059\u3002\u82b1\u7c89\u306b\u7e70\u308a\u8fd4\u3057\u66b4\u9732\u3055\u308c\u308b\u3068\u9f3b\u7c98\u819c\u306f\u5c11\u3057\u305a\u3064\u30a2\u30ec\u30eb\u30b2\u30f3\u3092\u3088\u308a\u654f\u611f\u306b\u611f\u3058\u308b\u3088\u3046\u306b\u306a\u308a\u3001\u5c11\u91cf\u306e\u82b1\u7c89\u3067\u3082\u6fc0\u3057\u304f\u53cd\u5fdc\u3059\u308b\u3088\u3046\u306b\u306a\u308a\u307e\u3059\u3002\u3053\u3046\u3057\u305f\u9f3b\u7c98\u819c\u306e\u5909\u5316\u3053\u305d\u304c\u3001\u30b7\u30fc\u30ba\u30f3\u3092\u91cd\u306d\u308b\u3054\u3068\u306b\u75c7\u72b6\u304c\u60aa\u5316\u3057\u3066\u3044\u304f\u6839\u672c\u539f\u56e0\u306a\u306e\u3067\u3059\u3002
\n\u4e00\u65b9\u3001\u82b1\u7c89\u75c7\u306e\u75c7\u72b6\u304c\u51fa\u308b\u524d\u306b\u3001\u307e\u305f\u306f\u51fa\u3066\u304b\u3089\u65e9\u3081\u306b\u6cbb\u7642\u3092\u958b\u59cb\u3059\u308b\u3068\u3001\u9f3b\u7c98\u819c\u306e\u30d2\u30b9\u30bf\u30df\u30f3\u53d7\u5bb9\u4f53\u306e\u767a\u73fe\u304c\u6291\u3048\u3089\u308c\u3001\u75c7\u72b6\u304c\u8efd\u304f\u306a\u308a\u307e\u3059\u3002\u3053\u308c\u304c\u300c\u521d\u671f\u7642\u6cd5\u300d\u3068\u547c\u3070\u308c\u308b\u3082\u306e\uff08\u203b1\uff09\u3002\u3053\u308c\u307e\u3067\u6bce\u5e74\u3001\u6700\u521d\u306f\u6211\u6162\u3057\u3066\u3057\u307e\u3063\u305f\u308a\u3001\u3075\u3068\u6c17\u304c\u3064\u3044\u305f\u3089\u75c7\u72b6\u306e\u30d4\u30fc\u30af\u3092\u8fce\u3048\u3066\u3044\u305f\u308a\u3057\u305f\u4eba\u306f\u3001\u4eca\u3059\u3050\u5e02\u8ca9\u85ac\u3092\u8cfc\u5165\u3059\u308b\u304b\u3001\u8033\u9f3b\u79d1\u3092\u53d7\u8a3a\u3059\u308b\u304b\u3057\u307e\u3057\u3087\u3046\u3002\u305d\u308c\u3060\u3051\u3067\u305a\u3044\u3076\u3093\u30e9\u30af\u306b\u306a\u308b\u306f\u305a\u3067\u3059\u3002
\n\u203b1 Mizuguchi H, Kitamura Y, Kondo Y, Kuroda W, Yoshida H, Miyamoto Y, et al. Preseasonal prophylactic treatment with antihistamines suppresses nasal symptoms and expression of histamine H receptor mRNA in the nasal mucosa of patients with pollinosis. Methods Find Exp Clin Pharmacol. 2010;32(10):745-8.
\n\u3055\u3066\u3001\u82b1\u7c89\u75c7\u306e\u6cbb\u7642\u3068\u3044\u3048\u3070\u3001\u98f2\u307f\u85ac\u3068\u3044\u3046\u5370\u8c61\u304c\u3042\u308b\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002\u3067\u3082\u3001\u82b1\u7c89\u75c7\u3067\u6700\u3082\u5f71\u97ff\u3092\u53d7\u3051\u308b\u306e\u306f\u9f3b\u306e\u300c\u4e0b\u9f3b\u7532\u4ecb(\u304b\u3073\u3053\u3046\u304b\u3044)\u300d\u3068\u3044\u3046\u90e8\u5206\u3067\u3001\u3082\u3063\u3068\u3082\u983b\u5ea6\u306e\u9ad8\u3044\u75c7\u72b6\u306f\u9f3b\u6c34\u30fb\u304f\u3057\u3083\u307f\u3067\u3059\u3002\u3053\u308c\u306f\u5438\u6c17\u304c\u9f3b\u304b\u3089\u5165\u308b\u3053\u3068\u3001\u4e0b\u9f3b\u7532\u4ecb\u304c\u9f3b\u3067\u6700\u3082\u5927\u304d\u304f\u3066\u8868\u9762\u7a4d\u306e\u5927\u304d\u3044\u69cb\u9020\u3067\u3042\u308b\u3053\u3068\u3001\u30a2\u30ec\u30eb\u30ae\u30fc\u306b\u3088\u308b\u30d2\u30b9\u30bf\u30df\u30f3\u306e\u4f5c\u7528\u304c\u9f3b\u3067\u76db\u3093\u306b\u884c\u308f\u308c\u308b\u3053\u3068\u304c\u539f\u56e0\u3067\u3059\u3002
\n\u3067\u3059\u304b\u3089\u3001\u79c1\u304c\u7b2c\u4e00\u306b\u304a\u3059\u3059\u3081\u3059\u308b\u306e\u306f\u3001\u70b9\u9f3b\u30b9\u30c6\u30ed\u30a4\u30c9\u85ac\u3067\u3059\u3002\u30b9\u30c6\u30ed\u30a4\u30c9\u3068\u805e\u304f\u3068\u4e0d\u5b89\u3092\u899a\u3048\u308b\u4eba\u3082\u3044\u308b\u3068\u601d\u3044\u307e\u3059\u304c\u3001\u70b9\u9f3b\u85ac\u306f\u9f3b\u306e\u7c98\u819c\u306b\u76f4\u63a5\u4f5c\u7528\u3057\u3001\u5168\u8eab\u3078\u306e\u5f71\u97ff\u306f\u307b\u3068\u3093\u3069\u3042\u308a\u307e\u305b\u3093\u3002
\n\u70b9\u9f3b\u30b9\u30c6\u30ed\u30a4\u30c9\u85ac\u306f\u3001\u98f2\u307f\u85ac\u3067\u3042\u308b\u300c\u7d4c\u53e3\u6297\u30d2\u30b9\u30bf\u30df\u30f3\u85ac\u300d\u3088\u308a\u3082\u3001\u9f3b\u6c34\u30fb\u9f3b\u3065\u307e\u308a\u30fb\u304f\u3057\u3083\u307f\u30fb\u9f3b\u306e\u304b\u3086\u307f\u306e\u3059\u3079\u3066\u306e\u75c7\u72b6\u3067\u512a\u308c\u305f\u52b9\u679c\u3092\u793a\u3057\u3001\u751f\u6d3b\u306e\u8cea\uff08QOL\uff09\u306e\u6539\u5584\u306b\u3082\u52b9\u679c\u7684\u3067\u3059\uff08\u203b2\uff09\u3002\u3057\u304b\u3082\u3001\u9f3b\u8154\u5185\u306e\u30a2\u30ec\u30eb\u30ae\u30fc\u53cd\u5fdc\u3092\u6291\u3048\u308b\u3053\u3068\u3067\u3001\u795e\u7d4c\u53cd\u5c04\u3092\u4ecb\u3057\u3066\u751f\u3058\u308b\u6d99\u76ee\u3084\u76ee\u306e\u304b\u3086\u307f\u306b\u3082\u6709\u52b9\u3002\u70b9\u9f3b\u85ac\u306f\u6b63\u3057\u3044\u65b9\u5411\u30fb\u91cf\u3067\u6bce\u65e5\u7d9a\u3051\u308b\u3053\u3068\u3067\u52b9\u679c\u304c\u51fa\u3066\u304d\u307e\u3059\u3002\u6307\u793a\u901a\u308a\u306b\u3057\u3063\u304b\u308a\u4f7f\u7528\u3057\u3001\u30b7\u30fc\u30ba\u30f3\u4e2d\u306f\u7d99\u7d9a\u3059\u308b\u3053\u3068\u3092\u610f\u8b58\u3057\u3066\u304f\u3060\u3055\u3044\u3002
\n\u305d\u308c\u3067\u3082\u9f3b\u3065\u307e\u308a\u304c\u307b\u3068\u3093\u3069\u6539\u5584\u3057\u306a\u3044\u4eba\u306f\u3001\u5225\u306e\u554f\u984c\u304c\u6f5c\u3093\u3067\u3044\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u4f8b\u3048\u3070\u3001\u9f3b\u306e\u4ed5\u5207\u308a\u306e\u9aa8\u304c\u66f2\u304c\u3063\u3066\u3044\u308b\u300c\u9f3b\u4e2d\u9694\u5f2f\u66f2\u75c7(\u3073\u3061\u3085\u3046\u304b\u304f\u308f\u3093\u304d\u3087\u304f\u3057\u3087\u3046)\u300d\u3001\u9f3b\u7c98\u819c\u304c\u6162\u6027\u7684\u306b\u539a\u304f\u816b\u308c\u3066\u3044\u308b\u300c\u80a5\u539a\u6027\u9f3b\u708e(\u3072\u3053\u3046\u305b\u3044\u3073\u3048\u3093)\u300d\u304c\u3042\u308b\u5834\u5408\u306f\u85ac\u3067\u708e\u75c7\u3092\u6291\u3048\u3088\u3046\u3068\u3057\u3066\u3082\u3001\u7269\u7406\u7684\u306a\u72ed\u7a84\u306f\u89e3\u6d88\u3055\u308c\u307e\u305b\u3093\u3002\u3053\u3046\u3057\u305f\u30b1\u30fc\u30b9\u3067\u306f\u624b\u8853\u304c\u5fc5\u8981\u3067\u3059\u3002\u8033\u9f3b\u54bd\u5589\u79d1\u3067\u76f8\u8ac7\u3057\u3066\u307f\u3066\u304f\u3060\u3055\u3044\u3002
\n\u203b2 Juel-Berg N, Darling P, Bolvig J, Foss-Skiftesvik MH, Halken S, Winther L, et al. Intranasal corticosteroids compared with oral antihistamines in allergic rhinitis: a systematic review and meta-analysis. Am J Rhinol Allergy. 2017;31(1):19-28.
\n\u4e00\u65b9\u3001\u82b1\u7c89\u75c7\u306e\u98f2\u307f\u85ac\u3067\u3042\u308b\u6297\u30d2\u30b9\u30bf\u30df\u30f3\u85ac\u306f\u9f3b\u3084\u76ae\u819a\u306e\u304b\u3086\u307f\u306b\u3082\u3063\u3068\u3082\u6709\u52b9\u3067\u3059\u304c\u3001\u305d\u306e\u9078\u3073\u65b9\u306b\u306f\u6ce8\u610f\u304c\u5fc5\u8981\u3067\u3059\u3002
\n\u3088\u304f\u3042\u308b\u52d8\u9055\u3044\u306b\u300c\u52b9\u304d\u76ee\u306e\u5f37\u3044\u85ac\u3092\u98f2\u3080\u3068\u7720\u304f\u306a\u308b\u300d\u3068\u3044\u3046\u3082\u306e\u304c\u3042\u308a\u307e\u3059\u3002\u6297\u30d2\u30b9\u30bf\u30df\u30f3\u85ac\u306f\u4f53\u8cea\u306b\u3088\u3063\u3066\u52b9\u304d\u65b9\u304c\u5927\u304d\u304f\u7570\u306a\u308a\u307e\u3059\u3002\u3042\u308b\u4eba\u306b\u3088\u304f\u52b9\u304f\u85ac\u304c\u81ea\u5206\u306b\u306f\u52b9\u304b\u306a\u304b\u3063\u305f\u308a\u3001\u4ed6\u306e\u4eba\u3067\u306f\u7720\u6c17\u304c\u51fa\u306a\u3044\u85ac\u3067\u3082\u81ea\u5206\u306f\u7720\u304f\u306a\u308b\u3001\u3068\u3044\u3046\u3053\u3068\u304c\u3081\u305a\u3089\u3057\u304f\u306a\u3044\u306e\u3067\u3059\u3002\u3060\u304b\u3089\u3001\u7720\u304f\u306a\u308b\u85ac\u3092\u9078\u3076\u5fc5\u8981\u306f\u3042\u308a\u307e\u305b\u3093\u3002
\n\u7279\u306b\u907f\u3051\u3066\u307b\u3057\u3044\u306e\u304c\u3001\u5e02\u8ca9\u306e\u7dcf\u5408\u611f\u5192\u85ac\u3084\u9f3b\u708e\u85ac\u306b\u542b\u307e\u308c\u308b\u7b2c\u4e00\u4e16\u4ee3\u6297\u30d2\u30b9\u30bf\u30df\u30f3\u85ac\uff08\u30af\u30ed\u30eb\u30d5\u30a7\u30cb\u30e9\u30df\u30f3\u3001\u30b8\u30d5\u30a7\u30f3\u30d2\u30c9\u30e9\u30df\u30f3\u7b49\uff09\u3067\u3059\u3002\u3053\u308c\u3089\u306f\u7720\u304f\u306a\u308b\u3060\u3051\u3067\u306a\u304f\u3001\u7720\u6c17\u3092\u81ea\u899a\u3057\u3066\u3044\u306a\u3044\u72b6\u614b\u3067\u3082\u6ce8\u610f\u529b\u3084\u53cd\u5fdc\u901f\u5ea6\u304c\u5ba2\u89b3\u7684\u306b\u843d\u3061\u308b\u3053\u3068\u304c\u5b9f\u8a3c\u3055\u308c\u3066\u3044\u307e\u3059\uff08\u203b3\uff09\u3002\u5e02\u8ca9\u306e\u300c\u25cb\u25cb\u9f3b\u708e\u30ab\u30d7\u30bb\u30eb\u300d\u3068\u3044\u3063\u305f\u88fd\u54c1\u306e\u591a\u304f\u306b\u3053\u306e\u6210\u5206\u304c\u5165\u3063\u3066\u3044\u307e\u3059\u306e\u3067\u3001\u8cfc\u5165\u524d\u306b\u6210\u5206\u8868\u793a\u3092\u3088\u304f\u78ba\u8a8d\u3057\u3066\u304f\u3060\u3055\u3044\u3002
\n\u82b1\u7c89\u75c7\u306e\u6cbb\u7642\u306b\u306f\u3001\u7b2c\u4e8c\u4e16\u4ee3\u6297\u30d2\u30b9\u30bf\u30df\u30f3\u85ac\uff08\u30d5\u30a7\u30ad\u30bd\u30d5\u30a7\u30ca\u30b8\u30f3\u3001\u30ed\u30e9\u30bf\u30b8\u30f3\u3001\u30bb\u30c1\u30ea\u30b8\u30f3\u3001\u30a8\u30d4\u30ca\u30b9\u30c1\u30f3\u7b49\uff09\u3092\u304a\u3059\u3059\u3081\u3057\u307e\u3059\u3002\u3053\u308c\u3089\u306e\u591a\u304f\u306f\u30c9\u30e9\u30c3\u30b0\u30b9\u30c8\u30a2\u3067\u3082\u8cfc\u5165\u3067\u304d\u307e\u3059\u3057\u3001\u8033\u9f3b\u79d1\u3092\u53d7\u8a3a\u3059\u308c\u3070\u9069\u5207\u306b\u51e6\u65b9\u3055\u308c\u307e\u3059\u3002\u7720\u6c17\u306a\u3069\u306e\u6c17\u306b\u306a\u308b\u526f\u4f5c\u7528\u304c\u3042\u308c\u3070\u3001\u540c\u3058\u7b2c\u4e8c\u4e16\u4ee3\u3067\u3082\u5225\u306e\u85ac\u306b\u5909\u3048\u308b\u3053\u3068\u3067\u6539\u5584\u3059\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002\u81ea\u5206\u306b\u5408\u3046\u85ac\u304c\u898b\u3064\u304b\u308b\u3088\u3046\u3001\u533b\u5e2b\u306b\u9060\u616e\u306a\u304f\u76f8\u8ac7\u3057\u3066\u304f\u3060\u3055\u3044\u3002
\n\u203b3 Shamil K, Prakruti P, Gandhi Anuradha M, Shah Bela J, Desai Chetna K. Old versus new antihistamines: effects on cognition and psychomotor functions. J Fam Med Prim Care. 2022;11(10):5909-5917.
\n\u305d\u3057\u3066\u76ee\u306e\u75c7\u72b6\u306b\u306f\u3001\u9f3b\u75c7\u72b6\u3068\u306f\u5225\u306e\u5bfe\u7b56\u304c\u5fc5\u8981\u306b\u306a\u308a\u307e\u3059\u3002\u98f2\u307f\u85ac\u306f\u9f3b\u3084\u76ae\u819a\u306e\u75c7\u72b6\u306b\u306f\u52b9\u679c\u3092\u767a\u63ee\u3057\u307e\u3059\u304c\u3001\u76ee\u306e\u304b\u3086\u307f\u30fb\u5145\u8840\u3078\u306e\u76f4\u63a5\u7684\u306a\u52b9\u679c\u306f\u9650\u5b9a\u7684\u3067\u3059\u3002\u76ee\u306e\u75c7\u72b6\u306b\u306f\u3001\u76f4\u63a5\u4f5c\u7528\u3059\u308b\u6297\u30a2\u30ec\u30eb\u30ae\u30fc\u70b9\u773c\u85ac\u3092\u4f7f\u3044\u307e\u3057\u3087\u3046\u3002
\n\u307e\u305a\u306f\u5185\u670d\u3068\u985e\u4f3c\u306e\u6297\u30d2\u30b9\u30bf\u30df\u30f3\u85ac\u306e\u542b\u307e\u308c\u305f\u70b9\u773c\u85ac\u304c\u304a\u3059\u3059\u3081\u3067\u3059\u30021\u65e52\uff5e4\u56de\u3001\u898f\u5b9a\u91cf\u3092\u7d99\u7d9a\u7684\u306b\u70b9\u773c\u3057\u307e\u3057\u3087\u3046\u3002\u304b\u3086\u307f\u304c\u3072\u3069\u3044\u5834\u5408\u306f\u30b9\u30c6\u30ed\u30a4\u30c9\u70b9\u773c\u85ac\u304c\u51e6\u65b9\u3055\u308c\u308b\u3053\u3068\u3082\u3042\u308a\u307e\u3059\u304c\u3001\u7d99\u7d9a\u7684\u306b\u4f7f\u3046\u3068\u773c\u5727\u304c\u9ad8\u304f\u306a\u3063\u3066\u8996\u795e\u7d4c\u3092\u5727\u8feb\u3057\u3066\u76ee\u304c\u898b\u3048\u3065\u3089\u304f\u306a\u308b\u300c\u30b9\u30c6\u30ed\u30a4\u30c9\u7dd1\u5185\u969c\u300d\u306b\u306a\u308b\u6050\u308c\u304c\u3042\u308a\u3001\u6700\u60aa\u306e\u5834\u5408\u306f\u5931\u660e\u3059\u308b\u30ea\u30b9\u30af\u3082\u3042\u308a\u307e\u3059\u3002\u3067\u3059\u304b\u3089\u3001\u773c\u79d1\u306e\u533b\u5e2b\u306b\u8a3a\u5bdf\u3092\u53d7\u3051\u305f\u3046\u3048\u3067\u306e\u4f7f\u7528\u304c\u304a\u3059\u3059\u3081\u3067\u3059\u3002
\n\u3082\u3046\u3072\u3068\u3064\u306e\u9078\u629e\u80a2\u3068\u3057\u3066\u3001\u300c\u30a2\u30ec\u30b8\u30aa\u30f3\u773c\u8edf\u818f\uff080.5\uff05\u30a8\u30d4\u30ca\u30b9\u30c1\u30f3\u5869\u9178\u5869\u773c\u77bc\u30af\u30ea\u30fc\u30e0\uff09\u300d\u304c\u3042\u308a\u307e\u3059\u3002\u5f93\u6765\u306e\u76ee\u85ac\u3068\u9055\u3044\u3001\u307e\u3076\u305f\u306b\u5857\u308b\u30bf\u30a4\u30d7\u3067\u3001\u76ee\u3092\u958b\u3051\u305a\u306b\u5c31\u5bdd\u524d\u306b1\u56de\u5857\u308b\u3060\u3051\u3067\u3059\u3002\u7279\u306b\u76ee\u85ac\u3092\u3046\u307e\u304f\u5dee\u305b\u306a\u3044\u5c0f\u3055\u306a\u304a\u5b50\u3055\u3093\u3001\u30b3\u30f3\u30bf\u30af\u30c8\u30ec\u30f3\u30ba\u4f7f\u7528\u4e2d\u306e\u65b9\u3001\u70b9\u773c\u304c\u96e3\u3057\u3044\u3054\u9ad8\u9f62\u306e\u65b9\u306b\u5411\u3044\u3066\u3044\u307e\u3059\u3002
\n\u3053\u3046\u3057\u305f\u65e2\u5b58\u306e\u6cbb\u7642\u3092\u5341\u5206\u306b\u8a66\u3057\u3066\u3082\u52b9\u679c\u304c\u5f97\u3089\u308c\u306a\u3044\u91cd\u75c7\u4f8b\u306b\u306f\u3001\u6ce8\u5c04\u85ac\u3067\u3042\u308b\u300c\u30aa\u30de\u30ea\u30ba\u30de\u30d6\uff08\u6297IgE\u6297\u4f53\u88fd\u5264\uff09\u300d\u3092\u4f7f\u3046\u3068\u3044\u3046\u9078\u629e\u80a2\u304c\u3042\u308a\u307e\u3059\u3002\u30a2\u30ec\u30eb\u30ae\u30fc\u306e\u5f15\u304d\u91d1\u3068\u306a\u308bIgE\u306b\u76f4\u63a5\u7684\u306b\u50cd\u304d\u304b\u3051\u3001\u91cd\u75c7\u30b9\u30ae\u82b1\u7c89\u75c7\u60a3\u8005\u306e\u9f3b\u75c7\u72b6\u30fb\u76ee\u306e\u75c7\u72b6\u304c\u6709\u610f\u306b\u6539\u5584\u3059\u308b\u3053\u3068\u304c\u56fd\u5185\u306e\u81e8\u5e8a\u8a66\u9a13\u3067\u3082\u78ba\u8a8d\u3055\u308c\u3066\u3044\u307e\u3059\uff08\u203b4\uff09\u3002\u5024\u6bb5\u304c\u9ad8\u3044\u306e\u304c\u96e3\u70b9\u3067\u3059\u304c\u3001\u4ed6\u306e\u6cbb\u7642\u304c\u52b9\u304b\u306a\u3044\u91cd\u75c7\u4f8b\u3067\u306f\u8a66\u3059\u4fa1\u5024\u304c\u3042\u308a\u307e\u3059\u3002
\n\u4e00\u65b9\u3001\u4ee5\u524d\u300c1\u30b7\u30fc\u30ba\u30f3\u52b9\u304f\u30a2\u30ec\u30eb\u30ae\u30fc\u306e\u6ce8\u5c04\u300d\u3068\u3057\u3066\u4f7f\u308f\u308c\u3066\u3044\u305f\u30b1\u30ca\u30b3\u30eb\u30c8\uff08\u30c8\u30ea\u30a2\u30e0\u30b7\u30ce\u30ed\u30f3\uff09\u7b4b\u8089\u6ce8\u5c04\u306f\u3084\u3081\u307e\u3057\u3087\u3046\u30022025\u5e7411\u6708\u3001\u540c\u7a2e\u306e\u30b9\u30c6\u30ed\u30a4\u30c9\u7b4b\u8089\u6ce8\u5c042\u88fd\u54c1\u306e\u30a2\u30ec\u30eb\u30ae\u30fc\u6027\u9f3b\u708e\u3078\u306e\u4fdd\u967a\u9069\u5fdc\u304c\u524a\u9664\u3055\u308c\u307e\u3057\u305f\u3002\u65e5\u672c\u8033\u9f3b\u54bd\u5589\u79d1\u982d\u9838\u90e8\u5916\u79d1\u5b66\u4f1a\u3082\u3053\u308c\u3092\u53d7\u3051\u3001\u30b1\u30ca\u30b3\u30eb\u30c8A\u306a\u3069\u306b\u3064\u3044\u3066\u3082\u300c\u63a8\u5968\u3055\u308c\u306a\u3044\u6cbb\u7642\u300d\u3068\u660e\u793a\u3057\u3066\u3044\u307e\u3059\uff08\u203b5\uff09\u3002\u3053\u306e\u85ac\u306e\u6700\u5927\u306e\u554f\u984c\u306f\u3001\u6ce8\u5c04\u5f8c\u306b\u526f\u4f5c\u7528\u304c\u51fa\u3066\u3082\u5143\u306b\u623b\u305b\u306a\u3044\u3053\u3068\u3002\u5b9f\u969b\u3001\u80a9\u306b\u6ce8\u5c04\u3057\u305f\u7d50\u679c\u3001\u7b4b\u8089\u304c\u840e\u7e2e\u3057\u3066\u3057\u307e\u3063\u305f\u3068\u3044\u3046\u8a71\u3082\u8033\u306b\u3057\u3066\u3044\u307e\u3059\u3002
\n\u203b4 Okubo K, Ogino S, Nagakura T, Ishikawa T. Omalizumab is effective and safe in the treatment of Japanese cedar pollen-induced seasonal allergic rhinitis. Allergol Int. 2006;55(4):379-86.\u203b5 \u65e5\u672c\u8033\u9f3b\u54bd\u5589\u79d1\u982d\u9838\u90e8\u5916\u79d1\u5b66\u4f1a \u4fdd\u967a\u533b\u7642\u59d4\u54e1\u4f1a\u300c\u30a2\u30ec\u30eb\u30ae\u30fc\u6027\u9f3b\u708e\u306b\u5bfe\u3059\u308b\u30b9\u30c6\u30ed\u30a4\u30c9\u7b4b\u8089\u6ce8\u5c04\u306b\u3064\u3044\u3066\u300d
\n\u307e\u305f\u3001\u8033\u9f3b\u79d1\u3067\u306e\u85ac\u306b\u3088\u308b\u6cbb\u7642\u3068\u4e26\u884c\u3057\u3066\u3001\u65e5\u5e38\u751f\u6d3b\u3067\u3082\u5bfe\u7b56\u3092\u3059\u308c\u3070\u3001\u82b1\u7c89\u75c7\u306e\u75c7\u72b6\u3092\u304b\u306a\u308a\u548c\u3089\u3052\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002\u4ee5\u4e0b\u306e\u3053\u3068\u306b\u6c17\u3092\u3064\u3051\u3066\u307f\u3066\u304f\u3060\u3055\u3044\u3002
\n\uff0e\u6cea\u597d\u3092\u9069\u5207\u306b\u4f7f\u3044\u3001\u82b1\u7c89\u3092\u5bb6\u306b\u5165\u308c\u306a\u3044\u82b1\u7c89\u3092\u4f53\u306b\u53d6\u308a\u5165\u308c\u306a\u3044\u3053\u3068\u304c\u3001\u82b1\u7c89\u75c7\u5bfe\u7b56\u306e\u7b2c\u4e00\u6b69\u3067\u3059\u3002\u82b1\u7c89\u98db\u6563\u671f\u306b\u3001\u5916\u3067\u30de\u30b9\u30af\u3092\u3057\u3066\u3044\u308b\u4eba\u306f\u591a\u3044\u3068\u601d\u3044\u307e\u3059\u3002\u30de\u30b9\u30af\u3092\u7d99\u7d9a\u7740\u7528\u3057\u305f\u82b1\u7c89\u75c7\u60a3\u8005\u3067\u306f\u3001\u91cd\u75c7\uff5e\u4e2d\u7b49\u75c7\u306e\u9f3b\u75c7\u72b6\u304c92\uff05\u304b\u308956\uff05\u306b\u6e1b\u5c11\u3057\u3001\u773c\u75c7\u72b6\u3082\u6539\u5584\u3057\u305f\u3068\u3044\u3046\u30c7\u30fc\u30bf\u304c\u3042\u308a\u307e\u3059\uff08\u203b6\uff09\u3002\u5e30\u5b85\u6642\u306b\u7384\u95a2\u5148\u3067\u8863\u670d\u3092\u6255\u3063\u3066\u304b\u3089\u5ba4\u5185\u306b\u5165\u308b\u3072\u3068\u624b\u9593\u3082\u5fd8\u308c\u305a\u306b\u3002
\n\u25b2\u7070\u9d50\u7e54\u30c8\u30ec\u30f3\u30ba\u3092\u3084\u3081\u3066\u773c\u93e1\u306b\u3059\u308b\u30b3\u30f3\u30bf\u30af\u30c8\u30ec\u30f3\u30ba\u4f7f\u7528\u8005\u3067\u306f\u76ee\u306e\u75c7\u72b6\u304c\u60aa\u5316\u3057\u3084\u3059\u3044\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u7279\u306b\u30bd\u30d5\u30c8\u30b3\u30f3\u30bf\u30af\u30c8\u30ec\u30f3\u30ba\u306e\u8868\u9762\u306b\u306f\u82b1\u7c89\u304c\u4ed8\u7740\u30fb\u84c4\u7a4d\u3057\u3084\u3059\u304f\u3001\u305d\u306e\u82b1\u7c89\u304c\u6d99\u3067\u6e7f\u308b\u3053\u3068\u3067\u30a2\u30ec\u30eb\u30b2\u30f3\u304c\u6eb6\u3051\u51fa\u3057\u3001\u7d50\u819c\u306b\u76f4\u63a5\u89e6\u308c\u7d9a\u3051\u308b\u72b6\u614b\u306b\u306a\u3063\u3066\u3057\u307e\u3046\u306e\u3067\u3059\u3002\u82b1\u7c89\u306e\u30b7\u30fc\u30ba\u30f3\u306f\u30b3\u30f3\u30bf\u30af\u30c8\u30ec\u30f3\u30ba\u3092\u306a\u308b\u3079\u304f\u907f\u3051\u3001\u773c\u93e1\u7740\u7528\u3092\u5fc3\u304c\u3051\u3066\u304f\u3060\u3055\u3044\u3002\u82b1\u7c89\u306e\u4fb5\u5165\u3092\u9632\u3050\u30ec\u30f3\u30ba\u30ab\u30d0\u30fc\u4ed8\u304d\u306e\u300c\u82b1\u7c89\u5bfe\u7b56\u773c\u93e1\u300d\u3082\u9078\u629e\u80a2\u306e\u3072\u3068\u3064\u3067\u3059\u3002
\n\uff29\uff0c\u0394\u3044\u3092\u7fd2\u6163\u306b\u3059\u308b\u9f3b\u3046\u304c\u3044\u306f\u5730\u5473\u3067\u3059\u304c\u6709\u52b9\u3067\u3059\u3002\u6700\u8fd1\u306f\u30c9\u30e9\u30c3\u30b0\u30b9\u30c8\u30a2\u3067\u30ad\u30c3\u30c8\u304c\u58f2\u3063\u3066\u3044\u307e\u3059\u306e\u3067\u3001\u3053\u308c\u3092\u8cb7\u3046\u306e\u304c\u304a\u3059\u3059\u3081\u3002\u65e5\u672c\u306a\u3089\u6c34\u9053\u6c34\u3067\u307b\u307c\u554f\u984c\u3042\u308a\u307e\u305b\u3093\u304c\u3001\u9577\u5e74\u4f7f\u3063\u3066\u3044\u306a\u3044\u6c34\u9053\u3001\u6d77\u5916\u306e\u6c34\u9053\u306e\u5834\u5408\u306f\u716e\u6cb8\u3057\u3066\u51b7\u307e\u3057\u305f\u304a\u6e6f\u3092\u3064\u304b\u3044\u307e\u3057\u3087\u3046\u3002\u8907\u6570\u306e\u81e8\u5e8a\u8a66\u9a13\u3092\u7d71\u5408\u3057\u305f\u89e3\u6790\u3067\u3001\u9f3b\u3046\u304c\u3044\u306b\u3088\u308b\u30a2\u30ec\u30eb\u30ae\u30fc\u6027\u9f3b\u708e\u306e\u75c7\u72b6\u6539\u5584\u304c\u78ba\u8a8d\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u5b89\u4fa1\u3067\u526f\u4f5c\u7528\u3082\u5c11\u306a\u304f\u3001\u4ed6\u306e\u6cbb\u7642\u306e\u88dc\u52a9\u3068\u3057\u3066\u53d6\u308a\u5165\u308c\u3084\u3059\u3044\u3067\u3059\u3002
\n\u3044\u9774\u8fb0\u308a\u7761\u7720\u6642\u9593\u3092\u3068\u308b\u82b1\u7c89\u75c7\u3068\u7761\u7720\u969c\u5bb3\u306f\u3001\u53cc\u65b9\u3092\u60aa\u5316\u3055\u305b\u308b\u60aa\u5faa\u74b0\u306e\u95a2\u4fc2\u306b\u3042\u308a\u307e\u3059\u3002\u30a2\u30ec\u30eb\u30ae\u30fc\u6027\u9f3b\u708e\u60a3\u8005\u306e\u7d044\u5206\u306e3\u306f\u7761\u7720\u969c\u5bb3\u3092\u5408\u4f75\u3057\u3066\u3044\u3066\u3001\u75c7\u72b6\u304c\u91cd\u3044\u307b\u3069\u7761\u7720\u306e\u8cea\u304c\u843d\u3061\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u3063\u3066\u3044\u307e\u3059\u3002\u305d\u3057\u3066\u7761\u7720\u4e0d\u8db3\u306f\u30a2\u30ec\u30eb\u30ae\u30fc\u53cd\u5fdc\u3092\u3055\u3089\u306b\u60aa\u5316\u3055\u305b\u307e\u3059\u3002\u5c31\u5bdd\u524d\u306e\u670d\u85ac\u3001\u82b1\u7c89\u3092\u5ba4\u5185\u306b\u6301\u3061\u8fbc\u307e\u306a\u3044\u5de5\u592b\u3001\u7a7a\u6c17\u6e05\u6d44\u6a5f\u306e\u6d3b\u7528\u304c\u304a\u3059\u3059\u3081\u3002\u7761\u7720\u74b0\u5883\u3078\u306e\u6295\u8cc7\u306f\u3001\u7fcc\u65e5\u306e\u75c7\u72b6\u306b\u76f4\u63a5\u8fd4\u3063\u3066\u304d\u307e\u3059\u3002
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\n\u203b6 Mengi E, Kara CO, Alptrk U, Topuz B. The effect of face mask usage on the allergic rhinitis symptoms in patients with pollen allergy during the COVID-19 pandemic. Am J Otolaryngol. 2022;43(1):103206.
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\n\u3053\u308c\u306f\u6bce\u65e5\u3001\u30b9\u30ae\u82b1\u7c89\u30a8\u30ad\u30b9\u3092\u5c11\u91cf\u305a\u3064\u820c\u306e\u4e0b\u306b\u6295\u4e0e\u3057\u30013\uff5e5\u5e74\u304b\u3051\u3066\u514d\u75ab\u3092\u518d\u6559\u80b2\u3059\u308b\u3068\u3044\u3046\u6839\u672c\u7684\u306a\u6cbb\u7642\u6cd5\u3067\u3059\u30023\u5e74\u9593\u306e\u6cbb\u7642\u3067\u3001\u82b1\u7c89\u75c7\u306e\u75c7\u72b6\u3092\u7d0446\uff05\u6291\u5236\u3067\u304d\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u3066\u3001\u6cbb\u7642\u3092\u3084\u3081\u305f\u5f8c\u3082\u52b9\u679c\u304c\u7d9a\u304f\u3068\u3044\u3046\u7279\u5fb4\u304c\u3042\u308a\u307e\u3059\uff08\u203b7\uff09\u3002
\n\u5168\u54e1\u304c\u5fc5\u305a\u85ac\u3092\u3084\u3081\u3089\u308c\u308b\u308f\u3051\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u304c\u3001\u75c7\u72b6\u304c\u8efd\u304f\u306a\u308b\u3001\u85ac\u304c\u5c11\u91cf\u3067\u6e08\u3080\u3068\u3044\u3063\u305f\u52b9\u679c\u306f\u671f\u5f85\u3067\u304d\u307e\u3059\u3002\u6cbb\u7642\u3092\u958b\u59cb\u3067\u304d\u308b\u306e\u306f\u3001\u82b1\u7c89\u306e\u98db\u6563\u304c\u7d42\u308f\u308b6\u6708\u4ee5\u964d\u304c\u76ee\u5b89\u3067\u3059\u3002\u52b9\u679c\u304c\u51fa\u308b\u306e\u306f\u534a\u5e74\uff5e1\u5e74\u5f8c\u304f\u3089\u3044\u306a\u306e\u3067\u3001\u6b21\u306e\u30b7\u30fc\u30ba\u30f3\u304b\u3089\u306b\u306a\u308a\u307e\u3059\u304c\u3001\u30e9\u30af\u306b\u306a\u3063\u305f\u3068\u3044\u3046\u4eba\u306f\u5c11\u306a\u304f\u3042\u308a\u307e\u305b\u3093\u30025\u6b73\u4ee5\u4e0a\u306a\u3089\u6cbb\u7642\u3092\u884c\u3046\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u306e\u3067\u3001\u8208\u5473\u304c\u3042\u308b\u65b9\u306f\u8033\u9f3b\u79d1\u30fb\u5c0f\u5150\u79d1\u3067\u76f8\u8ac7\u3057\u3066\u307f\u3066\u304f\u3060\u3055\u3044\u306d\u3002
\n\u203b7 Sakurai D, Ishii H, Shimamura A, Watanabe D, Yonaga T, Matsuoka T. Sublingual immunotherapy for Japanese cedar pollinosis: current clinical and research status. Pathogens. 2022;11(11):1313.
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